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dc.contributor.authorSaeedi Ghomi, M. H.
dc.date.accessioned2017-06-06T13:40:16Z
dc.date.available2017-06-06T13:40:16Z
dc.date.created1976
dc.date.issued1976
dc.identifier.urihttp://knowledgecommons.lakeheadu.ca/handle/2453/2298
dc.description.abstractThis thesis is concerned with the preliminary studies in the synthesis of a monoterpenoid alkaloid, chaksine, Ethyl 2-methylcyclohexanone-6-carboxylate (XI) was hydroxymethylated with formaldehyde to give Ethyl 2-methyl~6-hydroxymethylcyclohexanone--6-Carboxylate (XII). Tosylation and cleavage of this product gave 2-methyl-6- carbethoxy-B-heptenoic (XIV) acid along with the diethyl ester (XIVa)» Ozonolysis of the diethyl ester yielded diethyl 2-keto-6-methyl pimelate (XV). A Wittig reaction v/ith diethyl cyanomethyl phosphonate (XVI) gave l-cyano-6~methyll- cyano-2, 6-dicarbethoxy-l-heptene (XVII). Other related studies involved: 1) Preparation of ethyl 2-methyl-6-vinylcyclohexanone-6-carboxylate (XXII), 2) A new method for preparation of 2-imidazolidones (XXIV). 3) Preparation of l-phenyl~2-aldehydo-6-methyl~l, 6-heptadiene (XXXIII) and l-n-butylthio-2-aldehydo-6-methyl-l, 6-heptadiene (XXXIX).
dc.language.isoen_US
dc.subjectChaksine
dc.titlePartial synthesis of chaksine / by M. H. Saeedi Ghomi. --
etd.degree.nameM.Sc.
etd.degree.levelMaster
etd.degree.disciplineChemistry
etd.degree.grantorLakehead University


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