Synthesis and cytotoxic activity of diosgenyl saponin analogues / by Matthew Kaskiw.
Kaskiw, Matthew J.
MetadataShow full item record
"Saponins are naturally occurring glycosides that are widely distributed in the plant kingdom and lower marine organisms. Saponins consist of a carbohydrate chain attached to either a steroid or triterpene aglycone. Diosgenyl saponins are among the most abundant steroidal saponins and have attracted much attention for a host of varying biological activities. In recent years, diosgenyl saponins have demonstrated anticancer activity in a variety of cancer cell lines. The antitumour effect of diosgenyl saponins is shown to be through apoptosis.