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Reactivity and mechanistic study of the Sonogashira coupling and Grignard-Sonogashira coupling reactions
The interest in studying enediyne systems was stimulated by the discovery of anti-cancer agents containing enediyne functionalities, such as esperamicin and dynemicin. These compounds have potential for use as anti-tumour ...
Study of heteroaromatic enediyne and substituted benzothiophene synthesis with a study of unusual H NMR signals in neomenthyl halides
The synthesis of a number of heteroaromatic enediynes has been examined using the Sonogashira coupling reaction. Alkynes were coupled to 2,3-dibromothiophene to yield a number o f hetero- and homo-disubstituted enediynes. ...
Synthesis and reactivity of enediynes
The discovery of a class natural products with anti-cancer properties, the enediynes, has stimulated interest in their research. Due to their cytotoxicity, these compounds are not feasible for use in cancer treatment, ...