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H2S S-sulfhydration of pyruvate carboxylase in gluconeogenesis and its regulation by Trx1

dc.contributor.advisorYang, Guangdong
dc.contributor.advisorWang, Rui
dc.contributor.authorJu, YoungJun
dc.date.accessioned2016-01-11T19:01:16Z
dc.date.available2016-01-11T19:01:16Z
dc.date.created2015
dc.date.issued2015
dc.identifier.urihttp://knowledgecommons.lakeheadu.ca/handle/2453/709
dc.description.abstractHydrogen sulfide (H2S), regarded as the third gasotransmitter, plays diverse physiological and pathological roles in the body along with another two gasotransmitters, including nitric oxide (NO) and carbon monoxide (CO). In the liver, cystathionine gamma-lyase (CSE) is the main enzyme to generate H2S. The functions of H2S in the liver are largely unknown even though many studies showed H2S and CSE are important in redox control of liver. S-sulfhydration, a novel post-translational modification of proteins, is now considered as an important mechanism of H2S effects under various physiological and pathological conditions.en_US
dc.language.isoen_USen_US
dc.subjectGasotransmittersen_US
dc.subjectHydrogen sulfideen_US
dc.subjectPyruvate carboxylaseen_US
dc.subjectThioredoxin 1en_US
dc.titleH2S S-sulfhydration of pyruvate carboxylase in gluconeogenesis and its regulation by Trx1en_US
dc.typeDissertation
etd.degree.nameDoctor of Philosophyen_US
etd.degree.levelDoctoralen_US
etd.degree.disciplineBiotechnologyen_US
etd.degree.grantorLakehead Universityen_US
dc.contributor.committeememberKhaper, Neelam
dc.contributor.committeememberQin, Wensheng


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