Browsing by Discipline
Now showing items 21-40 of 58
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Enhancing biomolecule production from Bacillus velezensis PhCL using low-cost agricultural residues as feedstock and improving biomass hydrolysis through enzyme mutagenesis
(2023)Bioproduction have been considered an alternative option for obtaining useful and eco-friendly chemicals for industrial applications. Bacillus velezensis, a trending bacterium first isolated in 2005, is well-known for ... -
Environmental Considerations for Wet Mining Peatlands in Northwestern Ontario
(2012-11-10)Signi cant changes in water quality were detected using a Before-After-Control-Impact (BACI) experimental design. Porewater showed increases in pH, alkalinity, conductivity (including Ca, Mg, K, Na), some metals (Sr, Ba, ... -
Experimental and numerical investigation of drug delivery and aerosol deposition in the mouth-throat airway using a pressurized metered dose inhaler (pMDI)
(2025)Inhalation therapy is a widely used and effective method for treating respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Among the various inhalation devices, pressurized metered-dose ... -
Experimental investigation of water entry of a solid object and sand particles
(2023)This thesis presents the results of two different approaches to water entry; first, in Part I, the results of the experimental investigation of the water entry of a solid object, a thick disk in stagnant water, are ... -
Exploration of inflammasomes as targets for therapy of Pseudomonas aeruginosa infection
(2018)Pseudomonas aeruginosa is a common Gram-negative opportunistic bacterial pathogen capable of infecting humans with compromised natural defenses and causing severe pulmonary disease. It is the major cause of severe chronic ... -
Exploring potential of freshwater microalgae in Northern Ontario for bioremediation and bioenergy production
(2024)Native freshwater microalgae play a crucial role in biofuel production due to their unique characteristics and environmental suitability. This study investigated the diversity of microalgae species in various freshwater ... -
Flow control of low-reynolds number airfoils using morphing surface
(2025)This thesis investigates the application of traveling wave surface morphing as an advanced active flow control method to enhance the aerodynamic performance of airfoils operating at low Reynolds numbers of 1000 and 20,000. ... -
Functional Imaging of the Lungs using Magnetic Resonance Imaging of Inert Fluorinated Gases
(2016)Fluorine-19 (19F) magnetic resonance imaging (MRI) of the lungs using inhaled inert fluorinated gases can potentially provide high quality anatomical and functional images of the lungs. This technique is able to visualize ... -
Functional lignin for coating and 3D printing
(2024)The abundance of lignin, aromatic structure, and multifunctional groups uniquely appeal for use in advanced sustainable functional materials. Currently, the available lignin is not derived from a lignin-first strategy; ... -
Fundamental studies of microalgal biofilm formation and microalgalbacterial membrane photobioreactors
(2024)Microalgae is one of the photoautotrophic microorganisms that has attracted significant attention in wastewater treatment and biofuel production. Although researchers claimed that microalgae cultivation in wastewater ... -
H2S as a novel biomarker and therapeutic target for asthma
(2015)Asthma is a chronic inflammatory disease with hyper-responsive bronchoconstriction and airway remodeling, leading to extensive airway narrowing. The pathophysiology of asthma remains unclear. The literature shows that the ... -
H2S S-sulfhydration of pyruvate carboxylase in gluconeogenesis and its regulation by Trx1
(2015)Hydrogen sulfide (H2S), regarded as the third gasotransmitter, plays diverse physiological and pathological roles in the body along with another two gasotransmitters, including nitric oxide (NO) and carbon monoxide (CO). ... -
A high throughput screening and characterization of laccase-producing bacterium Serratia quinivorans AORB19 that exhibits lignin degradation traits, dye decolorization efficiency, and enhanced laccase production in biomass
(2023)Laccase (EC 1.10.3.2) assumes a vital role in the degradation of lignin by utilizing oxygen as an oxidant and catalyzing bond cleavage in both phenolic and nonphenolic lignin model compounds. However, their industrial ... -
Humoral immunity in patients with chronic kidney disease and their response to pneumococcal immunization
(2020)In northwestern Ontario the Indigenous First Nations (FN) population have an increased prevalence of chronic kidney disease (CKD). There is an increased rate of infectious disease caused by Streptococcus pneumoniae ... -
Hydrogen sulfide modulates gluconeogenesis and mitochondrial biogenesis in mouse primary hepatocytes
(2016)Among many endogenous substances that regulate hepatic energy production is the gasotransmitter hydrogen sulfide (H2S). In the liver, H2S production is largely catalyzed by cystathionine γ-lyase (CSE) and, to a lesser ... -
Improving Novel Gene Discovery in High-Throughput Gene Expression Datasets
(2012-11-10)High-throughput gene expression datasets (including RNA-seq and microarray datasets) can quantify the expression level of tens of thousands of genes in an organism, which allows for the identification of putative functions ... -
Induction of actinobacterial enzymes for enhanced biological depolymerization of polyethylene terephthalate plastics
(2025)Polyethylene terephthalate (PET), a widely used plastic, has been accumulating in the environment at an alarming rate, posing significant ecological challenges. This research addresses PET pollution through a biological ... -
Interaction of lignin derivatives with polymers, ions and soft surfaces in aqueous systems
(2021)Lignin is one of the most abundant biopolymers on earth which has recently gained considerable attention due to its unique potentials to be used in many applications. Many efforts have been made in improving the compatibility ... -
Investigation of drug aerosol size, delivery, and deposition in the mouth-throat airway using a soft mist inhaler (SMI): an experimental and numerical study
(2024)Respiratory drug delivery has been a key area of research for several decades, driven by the high prevalence of pulmonary diseases and the superior treatment efficiency offered by this approach. However, despite its ... -
Investigation on anti-proliferative effect of gyrophoric acid from the lichen Umbilicaria muhlenbergii on cancer cells
(2021)Natural products, including primary and secondary metabolites, are small molecules produced by any organism. As important sources of drug components, natural products may be isolated to small fractions with different ...
