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The carcinogenic properties of naturally occurring human papillomavirus 16 E6 oncogene variants
(2013-02-03)
Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical cancer, which is the result of expression of the E6 and E7 oncogenes. Here we challenged the dogma that the oncogenic protein ...
A combined method for establishing keratinocyte cultures from cervical biopsy specimens and creating patent-derived 3-dimensional organotypic raft cultures
(2018)
High-risk types of human papillomavirus (HPV) are responsible for nearly all instances of cervical cancer, and a significant proportion of head and neck cancers. Studying HPV in the laboratory requires the cultivation of ...
Aspects of infectious agents and cancer : effects of human Papillomavirus 16 and Escherichia coli on the innate immune defense of human keratinocytes
(2012-11-10)
Persistent human papillomavirus (HPV) is the causative agent of cervical cancer and bacterial vaginosis (BV) caused by Escherichia coli (E. coli ) has been implicated as a contributing factor. The innate immune system is ...
Differential response of two common human papillomavirus 16 E6 variants to small interfering RNA
(2014-01-22)
High-risk human papillomaviruses (HPVs), such as HPV16, are implicated in causing virtually all cases of cervical cancer. Molecular therapies capable of targeting HPV16 E6 oncoprotein expression can selectively eliminate ...