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Evaluating the utility of a point of care device to assess physiological differences among wild boreal fishes
(2022)
With the increasing risk of anthropogenic impacts in boreal ecosystems there is a
need for tools to rapidly assess impacts on organisms and properly inform resource
managers. Though well-researched, the i-STAT a portable ...
Pre-clinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density
(2022)
Selective androgen receptor modulators (SARMs) are important hypertrophic
molecules that pose as potential treatments for many types of myopathy and osteopathy.
The aim of this study was to determine if the SARM RAD140 ...
The effects of climate change on the growth and spawning phenology of fishes in aquatic boreal environments
(2022)
Global climate change is occurring and observed warming patterns have had significant
impacts on aquatic environments as trends in water temperature are closely related to trends in
air temperature. In ectothermic organisms ...
Neutrophils in the interface between innate and adaptive immunity in response to Haemophilus influenzae type a
(2022)
Haemophilus influenzae type a (Hia) is a bacterial human pathogen that has emerged as a
significant cause of invasive disease in Canadian Indigenous populations. Protection against
encapsulated bacteria such as Hia is ...
Evaluation of Anti-E6 Single Domain Antibodies for the Treatment of Human Papillomavirus-related Cancer
(2022)
The HPV16 genome encodes two oncoproteins, E6 and E7, which are essential for viral
carcinogenesis. While E7 promotes cell proliferation, E6 abolishes the resulting p53-dependent
apoptotic response. We hypothesized that ...
Invasive spiny water flea (Bythotrephes cederströmii) and their impacts on young-of-year walleye (Sander vitreus) growth
(2022)
Invasive species are a major threat to aquatic ecosystems, costing an estimated $3.6
billion in impacts across Ontario. In particular, the predatory cladoceran Bythotrephes
cederströmii (Bythotrephes hereafter) has had ...