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Computational tools for the high-throughput identification of protein-targeted drugs and probes
(2015-08-04)
This thesis is comprised of three projects that are driven by a common theme, which is the use of computational tools in aiding molecular probe and drug design. In the first project, the feasibility of using molecular ...
Potential dual purpose molecular probe for HPV16 E6: a computational and experimental approach
(2015-08-05)
The goal of this project is to find a molecular probe for HPV variant 16 protein E6. This
goal is accomplished using a combination of Virtual Ligand Screening (VLS) and experimental
ligand binding assays.
Protein E6 is ...
Development of multi-probe fluorescence-based assay for boNTA detection
(2015-08-05)
Botulinum neurotoxins (BoNTs) cause the lethal disease botulism through the inhibition of acetyl choline secretion by the cleavage of crucial SNARE proteins. Determination of critical residues in the protein sequence of ...
Self-assembled thin films of thiocyanate and selenocyanate bithiophenes
(2015-06-15)
Presented herein is the organic synthesis and thin film (TF) assembly of six alkyl-substituted
thiocyante and selenocyante bithiophene molecules: NCSe-T2-Hx, NCS-T2-Hx, NCS-Hx-T2-Hx, NCSe-
Hx-T2-Hx, NCS-Hx-T2-Hx-SCN and ...
Synthesis and electrochemical study of Ptlr and PtRu nanomaterials
(2015)
The rapidly growing need for clean energy on a global scale has led to the emergence of
new fields of scientific research to facilitate the discovery and development of novel energy sources, such as fuel cells, which ...
Wastewater Treatment and Water Quality Assessment Through Electrochemical Approaches
(2015)
The protection of water resources is becoming one of the most critical issues afflicting people
globally. Novel, robust, efficient, and environmentally compatible technologies for the
treatment of wastewater and the ...
The Effect of Pesticides on the Degradation of Oxobiodegradable Agricultural Mulch Films
(2015)
Oxobiodegradable agriculture mulch films made from polyethylene (PE) are known to
have many benefits for agriculture practice, including increased yields and resource efficiency,
without the drawback of removing the ...
Cross-coupling reactions: synthesis and photoactivity of enediynes
(2015-02-02)
The syntheses of a number of photoactive enediynes using the Sonogashira Coupling reaction are described. Alkynes with different characteristics were coupled to 2-bromoiodobenzene to yield the desired drugs. The enediyne’s ...
The Synthesis and kinetic evaluation of lysosomotropic substrate-based probes for cathepsins B and L
(2015-10-21)
Members of the cathepsin family of cysteine proteases are gaining interest as potential imaging biomarkers and drug targets due to their multifunctional roles in a range of diseases such as cancer, asthma and arthritis. ...
Synthesis and modification of TiO2 and WO3 based nanostructured materials for environmental applications
(2015-10-21)
TiO2 and WO3 based nanomaterials are highly attractive for various applications encompassing photocatalysis, electrochromic devices, dye sensitized solar cells, hydrogen production, and sensing applications due to their ...