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Novel toll-like receptor 4 ligands: synthesis, biological studies and applications in molecular vaccines
(2015-06-15)
Lipid A, a unique disaccharide glycolipid, is the active principle of Gram-negative
bacterial lipopolysaccharide in activating the innate immune response via Toll-like
receptor 4 (TLR4). Given the important role that ...
Synthesis of novel Lipid A analogs as potential ligands for toll-like receptor 4
(2009)
Lipid A, the glycolipid component of Gram-negative bacterial lipopolysaccharide has been shown to engage the Toll-like receptor 4 (TLR4) signalling pathway. While this signalling cascade results in cellular mediators which ...