Browsing by Advisor
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Assessing in vitro DNA repair methods / by Ryan Lehto.
(2010)The DNA molecule is constantly under attack from endogenous and exogenous sources leading to degradation by a variety of forms of damage. In this study current methods of in vitro DNA repair methods were evaluated for ... -
Detection and characterization of DNA damage
(2009)The DNA molecule is constantly subjected to endogenous and exogenous sources of damage which if left unrepaired can lead to genotoxic and cytotoxic outcomes. These lesions have been implicated in the development of numerous ... -
Detection of Deoxyribonucleic Acid Damage Induced by Metal Ion Interactions and Repair of Metal Ion Deoxyribonucleic Acid Cross-links
(2010-08-17)There are many forms of DNA damage. One of these, DNA-metal cross-links are particularly problematic as they not only affect the tautomeric structure of DNA, but can also inhibit enzymatic activity and block amplification ... -
The effect of metformin on absolute telomere length
(2018)In this study, the relationship between average absolute telomere length and metformin use was examined. Human blood samples were obtained from 106 participants ranging from 42-100 years old. Samples were split into four ... -
Evaluating DNA Extraction and Analysis of Ancient Seeds: A Study in Peach
(2015)The peach (Prunus persica) is one of the most widely grown stone fruit in the world but its origin and domestication is still being debated. Genetic research has focused on identifying desirable genes for agricultural ... -
The functional interpretation of quartz and amethyst artefacts from the Mackenzie I site (DdJf-9)
(2017)Mackenzie I is the largest excavated archaeological site that is attributed to the Lakehead Complex, the first known occupants of the area surrounding modern day Thunder Bay, Ontario. As such, it has garnered much academic ... -
Genetic profiling variation caused by tissue type, error, and damage
(2006)Genetic profiling variations caused by tissue type, error, and damage have been studied only minimally in the past. Even though it is well accepted that damage to the DNA molecule and PCR induced error occur, little focus ... -
Improving genetic profiling techniques for low copy number DNA / by Shana Hayter.
(2007)The extraction of DNA from ancient samples presents many obstacles to the analyst. These samples are often subjected to many years of harsh environmental conditions and many forms of damage resulting in low copy number and ... -
Investigating the qualities of raw lithic material and the selection pressures of lithic materials from the gunflint formation, in Ontario Canada
(2018)The study of stone tools in archaeology has advanced considerably in recent years, from the early ideas of what makes a stone anthropogenically modified to using advanced spectroscopic techniques to help determine ancient ... -
Long term DNA storage evaluation and methodology
(2021)DNA preservation over the long term is a considerable problem for many fields that still lack a viable, cost-effective, long-term solution. The considerable amount of genetic material that is currently aging in facilities ... -
Molecular detection and identification of parasites involved in human disease
(2006)The detection and identification of disease-causing parasites via DNA and the polymerase chain reaction (PCR) offers a new approach for quick and efficient disease diagnosis. Three nucleic acid based technologies have ... -
Multi-analytical residue analysis of the trihedral adze: a case study for the introduction of new methodologies in boreal forest archaeology
(2015-06-15)This thesis aims to evaluate the use of multi-analytical residue analysis in archaeological investigations in the Boreal Forest through the examination of a specific artifact class – the trihedral and related adze tool ... -
A multiomic approach to paleogenetic investigation of ancient North American bison
(2018)Twelve ancient bison bone samples from north-central North America were examined using genetic and proteomic sequencing to determine relationships to other bison populations. Mitochondrial DNA sequences suggest a genetic ... -
Nature and structure of DNA through the process of degradation
(2004)The identification and characterisation of DNA damage is of great importance to molecular research and has significant implications for clinical and forensic fields. From the moment of cell death, DNA incurs many forms ... -
Optimizing the sensitivity and specificity of genetic disease detection / by Travis E. Marion.
(2007)The molecular diagnosis of genetic disease is of great importance to the field of medicine and medical research. Though many rare inherited diseases have been described in the medical literature, the inheritance pattern ... -
Phytochemical analysis of boreal forest flora of Northwestern Ontario, Canada
(2017)The following research document has been written in the format of a thesis by publication. As such, there is an introductory and concluding chapter to provide addition information and context to the scope of the study, ... -
Recovering the proteome of archived biomedical specimens
(2021)While several proteomic studies have undertaken the challenge of analyzing formalin fixed paraffin embedded (FFPE) tissue, few have developed optimized protocols for studying FFPE human brain tissue. This study will ... -
Towards the optimisation of a detection system for markers linked to neural tube defects
(2008)Neural tube defects are the second most common birth defect of the central nervous system. The aim of this research is to design and optimise a novel detection system to analyse five markers that have been shown to be ...