Browsing by Committee Member
Now showing items 1-9 of 9
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18F Radiolabeling of epidermal growth factor receptor-tyrosine kinase inhibitor anti-cancer drugs for therapeutic outcome studies
(2023)Epidermal growth factor receptor is a transmembrane protein with tyrosine kinase activity that plays a vital role in the proliferation, differentiation, and survival of normal cells. When mutations in this protein occur, ... -
Assessing and characterizing the inductive effect through silicon containing backbones and on silicon reactivity
(2014-01-22)This thesis describes a study of the inductive effect in derivatives of bicyclo[1.1.1.]pentane; chosen because it eliminates any possibility of conjugation between the substituent and probe, and keeps the steric effect ... -
Biological studies of muramyl dipeptide analogues as potential ligands for NOD2 receptor
(2023)The human body’s survival against various foreign disease-causing organisms solely depends on the protection provided by our body's immune system. Our body's complex yet effective immune system comprises cells, molecules ... -
Design, synthesis, and evaluation of novel aurora kinase inhibitors for cancer diagnosis and therapy
(2024)Cancer is the second leading cause of death globally. Advances in cancer diagnosis and therapeutics plays a critical role in global health and a patient’s life. Aurora kinases, as mitotic kinases, regulate multiple mitotic ... -
A device for performing sonoporation on adherent cell cultures
(2015-06-15)Sonoporation is a method for inducing a transient increase in the permeability of cell membranes to otherwise impermeable compounds using ultrasound. This technique has therapeutic potential as it allows for localized ... -
Insights into subtype selectivity of aurora kinase ligands from molecular dynamics simulation
(2024)Aurora kinases are phosphotransferase enzymes that play essential roles in cell division. There are three members of Aurora kinases in mammalian cells: Aurora A, Aurora B and Aurora C. The overexpression of Aurora kinases ... -
Pathogen-host omics analyses of human papillomavirus type 16 sub-lineages in a human epithelial organoid model
(2019)Pathogens such as human papillomaviruses (HPVs) have co-evolved with their hosts and form a molecular basis for common diseases. Persistent infection with the “high-risk” HPV type 16 (HPV16) is a potent cause of anogenital ... -
Substituent descriptors from the topology of the electron density
(2021)This work focuses on determining the suitability of functional group properties from the Quantum Theory of Atoms in Molecules (QTAIM) as descriptors for use in machine learning and linear regression analyses. These were ... -
Synthesis and electrochemical study of Ptlr and PtRu nanomaterials
(2015)The rapidly growing need for clean energy on a global scale has led to the emergence of new fields of scientific research to facilitate the discovery and development of novel energy sources, such as fuel cells, which ...
