Browsing by Committee Member
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Activity of liposomal taxol against breast cancer cells / by Melanie Heney.
(2007)Taxol (paclitaxel) is one of the most effective chemotherapeutic agents used for the treatment of multiple cancers, including breast, ovarian, and, non-small-cell lung cancer. However, development of taxol resistance with ... -
Assessing in vitro DNA repair methods / by Ryan Lehto.
(2010)The DNA molecule is constantly under attack from endogenous and exogenous sources leading to degradation by a variety of forms of damage. In this study current methods of in vitro DNA repair methods were evaluated for ... -
The carcinogenic properties of naturally occurring human papillomavirus 16 E6 oncogene variants
(2013-02-03)Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical cancer, which is the result of expression of the E6 and E7 oncogenes. Here we challenged the dogma that the oncogenic protein ... -
Comparing Canonical and Dicer Substrate Small Interfering RNA and Their Effects on the Silencing of Two Common Human Papillomavirus 16 E6 Variants
(2015)High-risk human papillomaviruses (HPVs), such as HPV16, cause nearly all cases of cervical cancer as well as a number of head and neck cancers. Over expression of the E6 oncoprotein helps drive the malignant phenotype, ... -
Cystathionine γ-lyase and hypoxia : implicating hydrogen sulfide in the hypoxic stress response
(2012-11-10)Hydrogen sulfide (H2 S) has emerged as a novel and important gasotransmitter for the cardiovascular system, where it is generated mainly by cystathionine γ-lyase (CSE). Abnormal metabolism and functions of the H2 S/CSE ... -
Development of bacterial systems for the production of cellulase and bioethanol
(2013-02-01)The wide varieties of extant bacterial species are often resistant to various environmental stresses. This demonstrates their frequent ability to adapt to and thrive in challenging environments. One such adaptation in ... -
Effect of biofilm and the role of rpoS on the survival of a p-Nitrophenol-degrading Pseudomonas putida / by Miranda Maki.
(2008)Pseudomonas putida is a Gram negative bacterium that can be found naturally in the environment as planktonic free-living cells, or in concert with other bacterial species in biofilms. In this study, the P. putida strain ... -
The effects of copper, calcium, and nickel on the olfactory response of fathead minnows: from neurophysiology to behaviour
(2014-01-22)The olfactory system is essential for a fish to be successful in an ecological context, and has been demonstrated to be sensitive to a variety of toxicants. The current biotic ligand model (BLM) for copper is an acute-toxicity ... -
Effects of different forms of prostate specific antigen on prostate cancer cell invasion / by Andrew Philip Cumming
(2007, c200)Prostate cancer (PCa) is one of the most common cancers in males around the world. Prostate-specific antigen (PSA) is a serine protease that is secreted at high levels by prostate epithelial cells and most prostate cancer ... -
Effects of elevated carbon dioxide concentration and light on biomass morphology and physiology of black spruce and white spruce seedlings
(2008)Carbon dioxide concentration and light interactions influence competition among boreal tree species, though little is known about the exact effects. The interactive effects of [CO 2 ] and light on growth, biomass production, ... -
Effects of water availability, longer photoperiod, and elevated [CO2] on the potential of the northward migration in trembling aspen (populus tremuloides michx.)
(2019)Based on climate envelope models, boreal tree species may migrate to higher latitudes (approximately 10˚N toward the north) in response to rapid climate changes by the end of this century. Multiple factors will likely ... -
Engineering fungi for boosting cellulase production and its potential industrial application
(2013-02-03)Bioconversion of lignocellulosic residues is initiated primarily by microorganisms such as fungi and bacteria which are capable of degrading lignocellulolytic materials. Fungi produce large amounts of extracellular ... -
Expression of oxidative stress response genes in Campylobacter jejuni biofilms / by David Andrew Brookes.
(2007)'Campylobacter jejuni' is a Gram-negative microaerophilic bacterium that is widely believed to be the number one cause of food borne gastroenteritis and diarrhea caused by bacteria. The ability to form biofilms may provide ... -
Fetal programming from sub-lethal radiation: glucose metabolism in the liver and brown adipose tissue
(2018)Exposure to ionizing radiation contributing to negative health outcomes is a widespread concern among the public, scientific community, and workers in the nuclear energy industry and diagnostic imaging field. However, ... -
Genetic profiling variation caused by tissue type, error, and damage
(2006)Genetic profiling variations caused by tissue type, error, and damage have been studied only minimally in the past. Even though it is well accepted that damage to the DNA molecule and PCR induced error occur, little focus ... -
Increased production of sugar streams from lignocellulosic materials through enzyme recycling
(2019)The Canadian pulp and paper mills generate over 1 million tons of primary sludge per year. This sludge mainly contains small cellulosic fibers and contaminants from pulp and paper manufacture and is usually disposed of by ... -
Lowbush blueberries in Northwestern Ontario as a commercial crop option in post-harvest peatlands
(2009-10-15)Wild blueberries (Vaccinium angustifolium Ait.) were investigated as a possible reclamation tool for post harvest peatlands in Northwestern Ontario, by genetic fingerprinting using microsatellite markers, an examination ... -
Method optimization and gene expression analysis for interferon Kappa mRNA in HPV-associated cervical disease / by Correne A. Decarlo.
(2008)Interferons (IFNs) are a common biological treatment option for many cancers as well as for human papillomavirus (HPV)-associated diseases, but current IFN treatments have not been optimized as disease progression subsists ... -
Modulation of Listeria monocytogenes biofilms by Pseudomonas spp. secreted substances / by Lauren Davey.
(2008)Listeria monocytogenes, a food-borne pathogen associated with severe disease, forms resistant biofilms which enable it to persist in food processing environments. Recently, surface active compounds and other microbially ... -
A multiomic approach to paleogenetic investigation of ancient North American bison
(2018)Twelve ancient bison bone samples from north-central North America were examined using genetic and proteomic sequencing to determine relationships to other bison populations. Mitochondrial DNA sequences suggest a genetic ...
