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Comparing Canonical and Dicer Substrate Small Interfering RNA and Their Effects on the Silencing of Two Common Human Papillomavirus 16 E6 Variants

Grochowski, Jessica (2015)

High-risk human papillomaviruses (HPVs), such as HPV16, cause nearly all cases of cervical cancer as well as a number of head and neck cancers. Over expression of the E6 oncoprotein helps drive the malignant phenotype, ...
Computational tools for the high-throughput identification of protein-targeted drugs and probes

Kamstra, Rhiannon (2015-08-04)

This thesis is comprised of three projects that are driven by a common theme, which is the use of computational tools in aiding molecular probe and drug design. In the first project, the feasibility of using molecular ...