Browsing by Advisor
Now showing items 1-6 of 6
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Computational tools for the high-throughput identification of protein-targeted drugs and probes
(2015-08-04)This thesis is comprised of three projects that are driven by a common theme, which is the use of computational tools in aiding molecular probe and drug design. In the first project, the feasibility of using molecular ... -
Design and evaluation of novel fluorescent molecular probes targeting cathepsin B
(2020)Lysosomal cysteine proteinase cathepsin B (CTB) is a member of the cysteine protease family known to participate in intracellular degradation processes and protein turnover in the lysosomes of healthy cells. Cathepsin B ... -
Development of multi-probe fluorescence-based assay for boNTA detection
(2015-08-05)Botulinum neurotoxins (BoNTs) cause the lethal disease botulism through the inhibition of acetyl choline secretion by the cleavage of crucial SNARE proteins. Determination of critical residues in the protein sequence of ... -
Efficacy of a multimolecular extraction from formalin-fixed paraffin-embedded tissue
(2021)As the genetic basis and gene expression components are being discovered for an increasing number of diseases and disorders there is a rising interest in using multiomic approaches to better understand these conditions. ... -
Modelling the molecular mechanisms of biocompatibility of artifical materials
(2015)One of the most common reasons for implant failure is immune rejection. Implant rejection leads to additional surgical intervention and, ultimately, increases health cost as well as recovery time. Within a few hours after ... -
Potential dual purpose molecular probe for HPV16 E6: a computational and experimental approach
(2015-08-05)The goal of this project is to find a molecular probe for HPV variant 16 protein E6. This goal is accomplished using a combination of Virtual Ligand Screening (VLS) and experimental ligand binding assays. Protein E6 is ...
