Browsing by Advisor
Now showing items 1-3 of 3
-
Design and evaluation of novel fluorescent molecular probes targeting cathepsin B
(2020)Lysosomal cysteine proteinase cathepsin B (CTB) is a member of the cysteine protease family known to participate in intracellular degradation processes and protein turnover in the lysosomes of healthy cells. Cathepsin B ... -
The design, synthesis and enzymatic evaluation of aminocyclitol inhibitors of glucocerebrosidase
(2014-01-22)Gaucher disease, the most common lysosomal storage disorder, is caused by mutations in the GBA gene which codes for the enzyme glucocerebrosidase (GCase) resulting in its deficiency. GCase deficiency results in the ... -
The Synthesis and kinetic evaluation of lysosomotropic substrate-based probes for cathepsins B and L
(2015-10-21)Members of the cathepsin family of cysteine proteases are gaining interest as potential imaging biomarkers and drug targets due to their multifunctional roles in a range of diseases such as cancer, asthma and arthritis. ...
