Browsing by Committee Member
Now showing items 1-11 of 11
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Coordination chemistry of bithiazole ligands: a comparative study of the 2,2’ and 4,4’ isomers
(2019)The bithiazole ring system consists of two thiazole (C3NS) aromatic rings. There are many regioisomers but two of potential interest for coordination chemistry are the 2,2’-bis(1,3-thiazole) and the 4,4’-bis(1,3-thiazole), ... -
Design and synthesis of small molecule ligands targeting protease-activated receptor 2 as potential diagnostic and therapeutic agents
(2021)Positron emission tomography (PET) imaging requires radionuclides (positron-emitters) labeled molecules (tracers) to image biochemical and physiological processes in vivo and helps diagnose diseases noninvasively. The ... -
The design of Zr metal-organic frameworks in the detection and neutralization of organophosphorus based nerve agents and pesticides
(2022)Organophosphates are ubiquitous in uses ranging from chemical warfare agents (CWA’s) to detergents. In between these two extreme uses lie organophosphorus-based agrichemicals, primarily pesticides, which are applied in ... -
Design, synthesis, and evaluation of novel aurora kinase inhibitors for cancer diagnosis and therapy
(2024)Cancer is the second leading cause of death globally. Advances in cancer diagnosis and therapeutics plays a critical role in global health and a patient’s life. Aurora kinases, as mitotic kinases, regulate multiple mitotic ... -
Design, synthesis, and evaluation of novel lysophosphatidic acid receptor-targeting small molecules as therapeutic and diagnostic agents
(2023)Breast cancer has the highest incidence rate of all cancers among Canadian women and accounts for nearly 14% of all cancer-related deaths in Canada. This type of cancer is often detected using medical imaging modalities ... -
Development of modulators targeting G proteincoupled receptors using a combination of conventional drug discovery methodologies and artificial intelligence techniques
(2023)Lysophosphatidic acid receptor 1 (LPA1) is one of six G protein-coupled receptors (GPCRs) in the LPA receptor family (LPA1-6) and is activated by lysophosphatidic acid (LPA). LPA1 is involved in a wide range of cellular ... -
The development of molecular probes for the in vitro and in vivo study of glucocerebrosidase
(2017)Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases in the world. Despite its prevalence, the disease is difficult to diagnose early with the vast majority of individuals already having significant ... -
Development of multi-probe fluorescence-based assay for boNTA detection
(2015-08-05)Botulinum neurotoxins (BoNTs) cause the lethal disease botulism through the inhibition of acetyl choline secretion by the cleavage of crucial SNARE proteins. Determination of critical residues in the protein sequence of ... -
Efficacy of a multimolecular extraction from formalin-fixed paraffin-embedded tissue
(2021)As the genetic basis and gene expression components are being discovered for an increasing number of diseases and disorders there is a rising interest in using multiomic approaches to better understand these conditions. ... -
Insights into subtype selectivity of aurora kinase ligands from molecular dynamics simulation
(2024)Aurora kinases are phosphotransferase enzymes that play essential roles in cell division. There are three members of Aurora kinases in mammalian cells: Aurora A, Aurora B and Aurora C. The overexpression of Aurora kinases ... -
The medical applications of hyperpolarized Xe and nonproton magnetic resonance imaging
(2024)Hyperpolarized 129Xe (HP 129Xe) magnetic resonance imaging (MRI) is a relatively young field which is experiencing significant advancements each year. Conventional proton MRI is widely used in clinical practice as an ...
