Browsing by Committee Member
Now showing items 1-20 of 22
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18F Radiolabeling of epidermal growth factor receptor-tyrosine kinase inhibitor anti-cancer drugs for therapeutic outcome studies
(2023)Epidermal growth factor receptor is a transmembrane protein with tyrosine kinase activity that plays a vital role in the proliferation, differentiation, and survival of normal cells. When mutations in this protein occur, ... -
Application of flow-through sold-phase-synthesis to the fluorescent labeling of amines with carboxylic and funtionalized bodipy dyes
(2024)The use of fluorophores for the labelling of biomolecules in living cells has become a key method for understanding processes in cellular biology. Synthetic fluorescent molecules can be introduced non-specifically to ... -
Assessing and characterizing the inductive effect through silicon containing backbones and on silicon reactivity
(2014-01-22)This thesis describes a study of the inductive effect in derivatives of bicyclo[1.1.1.]pentane; chosen because it eliminates any possibility of conjugation between the substituent and probe, and keeps the steric effect ... -
Coordination chemistry of bithiazole ligands: a comparative study of the 2,2’ and 4,4’ isomers
(2019)The bithiazole ring system consists of two thiazole (C3NS) aromatic rings. There are many regioisomers but two of potential interest for coordination chemistry are the 2,2’-bis(1,3-thiazole) and the 4,4’-bis(1,3-thiazole), ... -
Copolymerization of pretreated kraft lignin and acrylic acid to produce flocculants for suspension and solution systems
(2017)The presence of dyes in the wastewater of textile industry poses a number of environmental concerns due to their toxic nature and the removal of dyes from the wastewater is a major challenge nowadays. Synthetic polymers ... -
Design and synthesis of small molecule ligands targeting protease-activated receptor 2 as potential diagnostic and therapeutic agents
(2021)Positron emission tomography (PET) imaging requires radionuclides (positron-emitters) labeled molecules (tracers) to image biochemical and physiological processes in vivo and helps diagnose diseases noninvasively. The ... -
Design, synthesis, and evaluation of novel lysophosphatidic acid receptor-targeting small molecules as therapeutic and diagnostic agents
(2023)Breast cancer has the highest incidence rate of all cancers among Canadian women and accounts for nearly 14% of all cancer-related deaths in Canada. This type of cancer is often detected using medical imaging modalities ... -
Development of an 18F radiolabeling method using solid phase chemistry
(2023)New radiotracers are constantly being developed to expand the clinical applications of positron emission tomography (PET). One of the challenges in the development of PET tracers is the incorporation of a positron emitting ... -
The development of molecular probes for the in vitro and in vivo study of glucocerebrosidase
(2017)Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases in the world. Despite its prevalence, the disease is difficult to diagnose early with the vast majority of individuals already having significant ... -
Effects of antioxidant vitamin supplementation on resistance exercise induced lipid peroxidation in trained and untrained participants
(2003)High intensity aerobic-type exercise produces oxygen free radicals that can cause damage to lipid membranes (lipid peroxidation) that may lead to many problems such as the inactivation of cell membrane enzymes, the ... -
Fabrication, characterization and electrochemical studies of nickel and nickel-based materials
(2017)Nickel is a naturally abundant transition metal and is very cost effective. This, along with mechanical and magnetic characteristics, and good catalytic activity in different applications, has made it an interesting non-noble ... -
Flocculation performance of lignin-acrylamide derivatives
(2019)Wastewater produced in different industries contains fine suspended particles that raise a number of environmental concerns due to their potential toxicity and physicochemical properties and make their removal from industrial ... -
Long term DNA storage evaluation and methodology
(2021)DNA preservation over the long term is a considerable problem for many fields that still lack a viable, cost-effective, long-term solution. The considerable amount of genetic material that is currently aging in facilities ... -
Recovering the proteome of archived biomedical specimens
(2021)While several proteomic studies have undertaken the challenge of analyzing formalin fixed paraffin embedded (FFPE) tissue, few have developed optimized protocols for studying FFPE human brain tissue. This study will ... -
Self-assembled thin films of thiocyanate and selenocyanate bithiophenes
(2015-06-15)Presented herein is the organic synthesis and thin film (TF) assembly of six alkyl-substituted thiocyante and selenocyante bithiophene molecules: NCSe-T2-Hx, NCS-T2-Hx, NCS-Hx-T2-Hx, NCSe- Hx-T2-Hx, NCS-Hx-T2-Hx-SCN and ... -
Sodium iodate response in ARPE-19 cells: an In vitro model of age-related macular degeneration
(2024)With the rise in aging populations worldwide, diseases of the eye like age-related macular degeneration (AMD) will continue to rise and the need to investigate ways to slow down the progression of the disease are at an ... -
Specific binding sites for [H Dexamethasone and [H17B-Estradiol [17-Beta (Greek symbol)] in the hypothalamus of juvenile rainbow trout, Oncorhynchus mykiss
(1999)In bony fishes such as the rainbow trout, Oncorhynchus mykiss, glucocorticoid (GC) and estrogenic hormones are associated with a variety of physiological functions. Most notable are effects of GCs which allow the animal ... -
A study in lignin capability to improve strength and water absorbency of starch polymers: a potential heat-resistant fluid-loss-controller in water based drilling fluids
(2021)In the oil and gas industries, drilling deep wells has rapidly become more significant to meet the global demand. The design of drilling fluids and choosing the proper additives are very important for the drilling operation's ... -
Substituent descriptors from the topology of the electron density
(2021)This work focuses on determining the suitability of functional group properties from the Quantum Theory of Atoms in Molecules (QTAIM) as descriptors for use in machine learning and linear regression analyses. These were ...
