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DC Field | Value | Language |
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dc.contributor.author | Saeedi Ghomi, M. H. | |
dc.date.accessioned | 2017-06-06T13:40:16Z | |
dc.date.available | 2017-06-06T13:40:16Z | |
dc.date.created | 1976 | |
dc.date.issued | 1976 | |
dc.identifier.uri | http://knowledgecommons.lakeheadu.ca/handle/2453/2298 | |
dc.description.abstract | This thesis is concerned with the preliminary studies in the synthesis of a monoterpenoid alkaloid, chaksine, Ethyl 2-methylcyclohexanone-6-carboxylate (XI) was hydroxymethylated with formaldehyde to give Ethyl 2-methyl~6-hydroxymethylcyclohexanone--6-Carboxylate (XII). Tosylation and cleavage of this product gave 2-methyl-6- carbethoxy-B-heptenoic (XIV) acid along with the diethyl ester (XIVa)» Ozonolysis of the diethyl ester yielded diethyl 2-keto-6-methyl pimelate (XV). A Wittig reaction v/ith diethyl cyanomethyl phosphonate (XVI) gave l-cyano-6~methyll- cyano-2, 6-dicarbethoxy-l-heptene (XVII). Other related studies involved: 1) Preparation of ethyl 2-methyl-6-vinylcyclohexanone-6-carboxylate (XXII), 2) A new method for preparation of 2-imidazolidones (XXIV). 3) Preparation of l-phenyl~2-aldehydo-6-methyl~l, 6-heptadiene (XXXIII) and l-n-butylthio-2-aldehydo-6-methyl-l, 6-heptadiene (XXXIX). | |
dc.language.iso | en_US | |
dc.subject | Chaksine | |
dc.title | Partial synthesis of chaksine | |
dc.type | Thesis | |
etd.degree.name | Master of Science | |
etd.degree.level | Master | |
etd.degree.discipline | Chemistry | |
etd.degree.grantor | Lakehead University | |
Appears in Collections: | Retrospective theses |
Files in This Item:
File | Description | Size | Format | |
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GhomiM1976m-1b.pdf | 11.44 MB | Adobe PDF | ![]() View/Open |
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