Please use this identifier to cite or link to this item: https://knowledgecommons.lakeheadu.ca/handle/2453/265
Title: The Role of free- and liposomal-N-acetycysteine in paraquat-induced cytotoxicity
Authors: Mitsopoulos, Panagiotis
Keywords: Paraquat;Toxicology;Herbicides;N-acetycysteine;Cell-mediated cytotoxicity;Liposomes;Oxidation-reduction reaction;Antioxidants
Issue Date: 10-Nov-2012
Abstract: Paraquat (PQ), one of the most commonly used herbicides worldwide, is hightly toxic to humans and exposure can result in severe clinical situations with no effective treatments available. The toxicity of PQ has been attributed to its ability to continuously produce reactive oxygen species (ROS) via redox cycling. Oxidants have been shown to induce the expression of several early response genes and to activate transcription factors, which may contribute to the inflammatory response associated with PQ injury.
URI: http://knowledgecommons.lakeheadu.ca/handle/2453/265
metadata.etd.degree.discipline: Biology
metadata.etd.degree.name: M.Sc.
metadata.etd.degree.level: Master
metadata.dc.contributor.advisor: Suntres, Zacharias
metadata.dc.contributor.committeemember: Khaper, Neelam
Law, David
Malek, Ladislav
Appears in Collections:Electronic Theses and Dissertations from 2009

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