Please use this identifier to cite or link to this item:
https://knowledgecommons.lakeheadu.ca/handle/2453/4830
Title: | Study of the activation of the inflammasome protein complex by Haemophilus influenzae Type a |
Authors: | Chahal, Simrun |
Keywords: | Haemophilus influenzae;Innate immune system;Inflammasome;Bacterial culture, inactivation and MOI |
Issue Date: | 2021 |
Abstract: | Haemophilus influenzae (Hi) is a gram-negative bacterium capable of causing severe invasive infection such as meningitis and is classified by the presence or absence of polysaccharide capsule. The polysaccharide capsule is the most important virulence factor for encapsulated strains. Hi serotype a (Hia) is an encapsulated form of Hi that is recognized as an important emerging pathogen with incidence of invasive disease similar to Hi serotype b (Hib) prior to the introduction of the Hib vaccination. Despite this, not much is known about how Hia interacts with the innate immune system and how it induces an inflammatory response. Non-typeable Hi (NTHi) (the unencapsulated form of Hi) has recently been shown to activate the innate immune system through a multiprotein complex known as inflammasome. As such, this study aimed to investigate if Hia activates this innate immune complex and how this differs in encapsulated versus unencapsulated strains and invasive versus non-invasive strains. |
URI: | https://knowledgecommons.lakeheadu.ca/handle/2453/4830 |
metadata.etd.degree.discipline: | Biology |
metadata.etd.degree.name: | Master of Science |
metadata.etd.degree.level: | Master |
metadata.dc.contributor.advisor: | Ulanova, Marina |
metadata.dc.contributor.committeemember: | Khaper, Neelam Leung, Kam |
Appears in Collections: | Electronic Theses and Dissertations from 2009 |
Files in This Item:
File | Description | Size | Format | |
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ChahalS2021m-1a.pdf | 5.76 MB | Adobe PDF | ![]() View/Open |
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