Please use this identifier to cite or link to this item: https://knowledgecommons.lakeheadu.ca/handle/2453/4905
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dc.contributor.advisorLaw, David-
dc.contributor.advisorMatheson, Carney-
dc.contributor.authorLehto, Ryan-
dc.date.accessioned2022-01-21T20:01:05Z-
dc.date.available2022-01-21T20:01:05Z-
dc.date.created2021-
dc.date.issued2021-
dc.identifier.urihttps://knowledgecommons.lakeheadu.ca/handle/2453/4905-
dc.description.abstractDNA preservation over the long term is a considerable problem for many fields that still lack a viable, cost-effective, long-term solution. The considerable amount of genetic material that is currently aging in facilities around the world continues to slowly degrade over time. New discoveries are being made based on genetic material recovered from ancient specimens, and new technologies are looking to store metadata in DNA; but all face this eventual problem of long-term stability. There is no “magic bullet” for preventing the various forms of DNA damage that accumulate over time, and all current technological solutions have tradeoffs. Each method of preparation, storage, and processing is chosen with the immediate downstream application as the priority, and all have shortcomings for overall preservation. Costs and space requirements continue to rise as more material is continuously accumulated, and furthermore, DNA damage studies often extrapolate their results into the future, giving models that may not be accurate. In this study, I investigate current methods and propose a potential new approach to address the problem. [...]en_US
dc.language.isoen_USen_US
dc.subjectDNA preservationen_US
dc.subjectDNA stabilityen_US
dc.subjectLong-term storage (DNA)en_US
dc.titleLong term DNA storage evaluation and methodologyen_US
dc.typeDissertationen_US
etd.degree.nameDoctor of Philosophyen_US
etd.degree.levelDoctoralen_US
etd.degree.disciplineBiotechnologyen_US
etd.degree.grantorLakehead Universityen_US
dc.contributor.committeememberGottardo, Christine-
Appears in Collections:Electronic Theses and Dissertations from 2009

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