Please use this identifier to cite or link to this item: https://knowledgecommons.lakeheadu.ca/handle/2453/5044
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dc.contributor.advisorUlanova, Marina-
dc.contributor.authorFerris, Courtney-
dc.date.accessioned2022-12-16T17:30:04Z-
dc.date.available2022-12-16T17:30:04Z-
dc.date.created2022-
dc.date.issued2022-
dc.identifier.urihttps://knowledgecommons.lakeheadu.ca/handle/2453/5044-
dc.description.abstractHaemophilus influenzae type a (Hia) is a bacterial human pathogen that has emerged as a significant cause of invasive disease in Canadian Indigenous populations. Protection against encapsulated bacteria such as Hia is mediated by the antigen-specific antibody response, in cooperation with innate immune mechanisms. Anti-capsular antibodies and complement opsonize bacteria for phagocytosis. Neutrophils are abundant innate immune cells primarily involved in bacterial clearance via opsonophagocytosis. Recent studies revealed they can modulate the adaptive immune response, but this function is poorly understood. Also, much is still unknown about the innate and adaptive immune responses to Hia and its polysaccharide capsule. As such, this study aimed to determine if Hia can activate the innate and adaptive immune responses through neutrophils and if these responses differ between encapsulated versus unencapsulated, or invasive versus non-invasive strains. [...]en_US
dc.language.isoen_USen_US
dc.subjectHaemophilus influenzae type aen_US
dc.subjectAdaptive immune responseen_US
dc.titleNeutrophils in the interface between innate and adaptive immunity in response to Haemophilus influenzae type aen_US
dc.typeThesisen_US
etd.degree.nameMaster of Scienceen_US
etd.degree.levelMasteren_US
etd.degree.disciplineBiologyen_US
etd.degree.grantorLakehead Universityen_US
dc.contributor.committeememberKhaper, Neelam-
dc.contributor.committeememberSchraft, Heidi-
Appears in Collections:Electronic Theses and Dissertations from 2009

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