Browsing by Advisor
Now showing items 1-14 of 14
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Cross-coupling reactions: synthesis and photoactivity of enediynes
(2015-02-02)The syntheses of a number of photoactive enediynes using the Sonogashira Coupling reaction are described. Alkynes with different characteristics were coupled to 2-bromoiodobenzene to yield the desired drugs. The enediyne’s ... -
Expansion of the applicability of the Truce-Smiles rearrangement
(2022)The Truce-Smiles rearrangement is a synthetically useful and easily performed reaction which can be used to condense multiple steps of a synthesis. The nucleophilic aromatic substitution in this reaction produces a chiral ... -
Local variation of trace element concentrations in Usnea subfloridana
(2012-11-10)A mensurative study into the local variability of trace element concentrations in the lichen Usnea subjloridana was conducted. Samples were collected from an Abies balsamea located in the Thunder B y region away from any ... -
Reactivity and mechanistic study of the Sonogashira coupling and Grignard-Sonogashira coupling reactions
(2002)The interest in studying enediyne systems was stimulated by the discovery of anti-cancer agents containing enediyne functionalities, such as esperamicin and dynemicin. These compounds have potential for use as anti-tumour ... -
Reactivity study of the palladium cross-coupling synthesis of enediynes
(1999)A reactivity study looking at various aspects of the palladium catalyzed (Sonogashira) reaction for die synthesis of enediynes was performed. Alkynes were coupled to 1,2- dichloro-, 1,2-dibromo- and 1,2-diiodobenzene. ... -
Ruthenium-Tris(Pyrazolyl)methane complexes as potential candidates for cancer chemotherapy agents
(2009)The MeCN ligands of complex 1 were substitutionally inert, however, under forcing conditions the DMSO ligands of complex 2 were displaced by chelating 1,2-bis(diphenylphosphino)ethane to produce complex 6. Structural ... -
Selected ion flow tube-mass spectrometry in plant volatile compound analysis
(2009-07-20)Four monoterpenes and two monoterpenoids, (+)- and DL-limonene, (1S)-(3) carene, terpinolene, cineol and rose oxide, respectively, were studied using selected ion flow tube-mass spectrometry. Specifically, the reactions ... -
The stereochemical impact of chiral ionic liquids on [2+2] photochemical cycloadditions and aldol reactions
(2020)Eight chiral ionic liquids have been prepared for use as solvents to test whether they can induce enantioselectivity in both photochemical [2+2] cycloadditions and aldol reactions using a variety of starting materials. ... -
Structural determinations by analytical analysis of 7-phosphanorbornadiene derivatives and amino acid enantiomers
(2000)The purpose of Chapter 1 is to create a bicyclic, two-coordinate phosphorus derivative in the form of a 2,3-benzo-l,4,5,6-tetraphenyl-7-phosphanorbomadiene anion and measure its experimental 3,P NMR chemical shift. This ... -
Study of heteroaromatic enediyne and substituted benzothiophene synthesis with a study of unusual H NMR signals in neomenthyl halides
(2004)The synthesis of a number of heteroaromatic enediynes has been examined using the Sonogashira coupling reaction. Alkynes were coupled to 2,3-dibromothiophene to yield a number o f hetero- and homo-disubstituted enediynes. ... -
Study of heteroaromatic enediyne and substituted benzothiophene synthesis with relative reactivity of substituted aryl iodides in the Sonogashira reaction
(2006)Enediyne compounds have captured the imagination of chemists since their discovery as a class of natural products. Because of their cytotoxicity, these compounds are not suitable for use in cancer treatment. As a result, ... -
Study of the effect of gamma irradiation on cellular metabolism by nuclear magnetic resonance spectroscopy
(2005)The phenomenon of NMR plays an important role in a number of different scientific and medical fields. Nuclear magnetic resonance has the ability to detect changes in tumour, and cell metabolism caused by both chemotherapy ... -
Synthesis and applications of room temperature ionic liquids
(2017)A variety of room temperature ionic liquids have been synthesized and applied to various reactions. Four of these ionic liquids were prepared in a chiral manner: [1-butyl-3- methylimidazolium][L-lactate], [1-butyl-3-me ... -
Synthesis and reactivity of enediynes
(2004)The discovery of a class natural products with anti-cancer properties, the enediynes, has stimulated interest in their research. Due to their cytotoxicity, these compounds are not feasible for use in cancer treatment, ...
