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Design and synthesis of small molecule ligands targeting protease-activated receptor 2 as potential diagnostic and therapeutic agents
(2021)Positron emission tomography (PET) imaging requires radionuclides (positron-emitters) labeled molecules (tracers) to image biochemical and physiological processes in vivo and helps diagnose diseases noninvasively. The ... -
Design, synthesis, and evaluation of novel lysophosphatidic acid receptor-targeting small molecules as therapeutic and diagnostic agents
(2023)Breast cancer has the highest incidence rate of all cancers among Canadian women and accounts for nearly 14% of all cancer-related deaths in Canada. This type of cancer is often detected using medical imaging modalities ... -
Development of modulators targeting G proteincoupled receptors using a combination of conventional drug discovery methodologies and artificial intelligence techniques
(2023)Lysophosphatidic acid receptor 1 (LPA1) is one of six G protein-coupled receptors (GPCRs) in the LPA receptor family (LPA1-6) and is activated by lysophosphatidic acid (LPA). LPA1 is involved in a wide range of cellular ...