Browsing by Advisor
Now showing items 1-5 of 5
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Design and synthesis of small molecule ligands targeting protease-activated receptor 2 as potential diagnostic and therapeutic agents
(2021)Positron emission tomography (PET) imaging requires radionuclides (positron-emitters) labeled molecules (tracers) to image biochemical and physiological processes in vivo and helps diagnose diseases noninvasively. The ... -
Design, synthesis, and evaluation of novel aurora kinase inhibitors for cancer diagnosis and therapy
(2024)Cancer is the second leading cause of death globally. Advances in cancer diagnosis and therapeutics plays a critical role in global health and a patient’s life. Aurora kinases, as mitotic kinases, regulate multiple mitotic ... -
Design, synthesis, and evaluation of novel lysophosphatidic acid receptor-targeting small molecules as therapeutic and diagnostic agents
(2023)Breast cancer has the highest incidence rate of all cancers among Canadian women and accounts for nearly 14% of all cancer-related deaths in Canada. This type of cancer is often detected using medical imaging modalities ... -
Development of modulators targeting G proteincoupled receptors using a combination of conventional drug discovery methodologies and artificial intelligence techniques
(2023)Lysophosphatidic acid receptor 1 (LPA1) is one of six G protein-coupled receptors (GPCRs) in the LPA receptor family (LPA1-6) and is activated by lysophosphatidic acid (LPA). LPA1 is involved in a wide range of cellular ... -
Insights into subtype selectivity of aurora kinase ligands from molecular dynamics simulation
(2024)Aurora kinases are phosphotransferase enzymes that play essential roles in cell division. There are three members of Aurora kinases in mammalian cells: Aurora A, Aurora B and Aurora C. The overexpression of Aurora kinases ...