Browsing by Advisor
Now showing items 1-12 of 12
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Adipose tissue remodeling in response to corticosterone and β3-adrenergic receptor agonist mirabegron
(2022)With the rise of metabolic diseases including obesity and type 2 diabetes, the need to investigate one of the most dynamic endocrine organs is critical for combating these diseases. Adipose tissue (AT) exists predominantly ... -
Cardiac oxidative stress and antioxidant status in response to radiation and monocrotaline induced cardiac dysfunction
(2016)Cardiovascular disease is the leading cause of death and disability worldwide. Oxidative stress has been implicated in many types of cardiovascular disease. Chronic cardiac stress conditions have been shown to be associated ... -
The cumulative effects of hypoxia and hyperglycemia on cardiac oxidative stress
(2014-01-22)Hyperglycaemia-induced oxidative stress plays an important role in cardiomyocyte cell death leading to cardiac dysfunction. Autophagy is an intracellular bulk degradation process and can be induced by stressors such as ... -
Cystathionine γ-lyase and hypoxia : implicating hydrogen sulfide in the hypoxic stress response
(2012-11-10)Hydrogen sulfide (H2 S) has emerged as a novel and important gasotransmitter for the cardiovascular system, where it is generated mainly by cystathionine γ-lyase (CSE). Abnormal metabolism and functions of the H2 S/CSE ... -
The effect of polyphenols on the angiotensin II receptor type 1 activation
(2017)Hypertension, an increase in blood pressure, can lead to many serious complications, one of which is heart failure. Angiotensin (Ang) II is associated with hypertension; specifically, the Ang II receptor type 1 (AGTR1) is ... -
The effect of secoisolariciresinol diglucoside on oxidative stress and inflammation in cardiac iron overload
(2013-02-01)Chronic cardiac iron overload directly correlates with cardiac dysfunction and may ultimately cause heart failure. Although recent studies have suggested that altered calcium homeostasis and increased reactive oxygen ... -
Fetal programming from sub-lethal radiation: glucose metabolism in the liver and brown adipose tissue
(2018)Exposure to ionizing radiation contributing to negative health outcomes is a widespread concern among the public, scientific community, and workers in the nuclear energy industry and diagnostic imaging field. However, ... -
Physiological outcomes of interleukin-6 in high fat diet and voluntary physical activity
(2014)Insulin resistance is the principle step towards the progression of type 2 diabetes, and has been linked to increased circulating levels of cytokines, leading to chronic low-grade inflammation. Specifically, in chronic ... -
Radiation response in cells derived from individuals with hereditary breast cancer / by Lindsay Sutherland.
(2008)Inherited germline mutations in the tumour suppressor gene BRCA1 (BReast CAncer susceptibility gene 1) can lead to an increased risk for various cancers. Evidence now suggests that epigenetic changes resulting in reduced ... -
Role of phenolic compounds on blue light induced retinal pigment cell damage: an in vitro study
(2020)Age-related macular degeneration (AMD) is a progressive eye disease that affects the macula, causing blurred central vision making it difficult for diagnosed patients to see fine details and have trouble with everyday ... -
Secoisolariciresinol diglucoside reduces cell death and upregulates antioxidants in cardiac iron overload
(2016)Iron is essential to many biological and metabolic processes used in all organisms, but excess iron can result in complications such as cirrhosis, diabetes, and heart failure. Cardiac iron overload has been linked to ... -
Sodium iodate response in ARPE-19 cells: an In vitro model of age-related macular degeneration
(2024)With the rise in aging populations worldwide, diseases of the eye like age-related macular degeneration (AMD) will continue to rise and the need to investigate ways to slow down the progression of the disease are at an ...
