Browsing by Advisor
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Reactivity and mechanistic study of the Sonogashira coupling and Grignard-Sonogashira coupling reactions
(2002)The interest in studying enediyne systems was stimulated by the discovery of anti-cancer agents containing enediyne functionalities, such as esperamicin and dynemicin. These compounds have potential for use as anti-tumour ... -
Reactivity study of the palladium cross-coupling synthesis of enediynes
(1999)A reactivity study looking at various aspects of the palladium catalyzed (Sonogashira) reaction for die synthesis of enediynes was performed. Alkynes were coupled to 1,2- dichloro-, 1,2-dibromo- and 1,2-diiodobenzene. ... -
Structural determinations by analytical analysis of 7-phosphanorbornadiene derivatives and amino acid enantiomers
(2000)The purpose of Chapter 1 is to create a bicyclic, two-coordinate phosphorus derivative in the form of a 2,3-benzo-l,4,5,6-tetraphenyl-7-phosphanorbomadiene anion and measure its experimental 3,P NMR chemical shift. This ... -
Study of heteroaromatic enediyne and substituted benzothiophene synthesis with a study of unusual H NMR signals in neomenthyl halides
(2004)The synthesis of a number of heteroaromatic enediynes has been examined using the Sonogashira coupling reaction. Alkynes were coupled to 2,3-dibromothiophene to yield a number o f hetero- and homo-disubstituted enediynes. ... -
Study of heteroaromatic enediyne and substituted benzothiophene synthesis with relative reactivity of substituted aryl iodides in the Sonogashira reaction
(2006)Enediyne compounds have captured the imagination of chemists since their discovery as a class of natural products. Because of their cytotoxicity, these compounds are not suitable for use in cancer treatment. As a result, ... -
Study of the effect of gamma irradiation on cellular metabolism by nuclear magnetic resonance spectroscopy
(2005)The phenomenon of NMR plays an important role in a number of different scientific and medical fields. Nuclear magnetic resonance has the ability to detect changes in tumour, and cell metabolism caused by both chemotherapy ... -
Synthesis and reactivity of enediynes
(2004)The discovery of a class natural products with anti-cancer properties, the enediynes, has stimulated interest in their research. Due to their cytotoxicity, these compounds are not feasible for use in cancer treatment, ...
