| dc.description.abstract | Previous research indicates that seizures cause transient
and in some cases, long lasting increases in the density of
benzodiazepine receptors in the brain. The present research
sought to discover the behavioural effects of diazepam (Valium),
one of the benzodiazepines, on rats in a conflict paradigm
following Metrazol induced seizures. A total of 82 SHS rats
(both sexes) were used in this 4(diazepam doses) X 2 (seizure
condition) X 2(sexes) factorial design. The conflict involved
the availability of food for 24 hour food deprived rats in a
brightly lit open field . Since diazepam is known to have an
anticonflict effect, it was hypothesized that animals
experiencing a seizure would demonstrate a greater anticonflict
response. Results showed significant main effects for diazepam
and seizure factors in food eaten, approaches to the food and in
the ratio between food eaten and approaches to the food.
However, the seizure condition animals showed less anticonflict
behaviour which is contrary to what was predicted. Significant
drug by seizure interactions were expected and confirmed. The
possible drug interactions at the level of the brain receptors
is discussed, as well as, the behaviour resulting from combining
central nervous system(CNS) stimulants with CNS depressants and
anxiolytics. | |
