Synthetic studies on chaksine

dc.contributor.advisor	Orr, D.
dc.contributor.author	Evans, John Bruce
dc.date.accessioned	2017-06-06T13:08:34Z
dc.date.available	2017-06-06T13:08:34Z
dc.date.created	1970
dc.date.issued	1970
dc.identifier.uri	http://knowledgecommons.lakeheadu.ca/handle/2453/2203
dc.description.abstract	This thesis is concerned with the preliminary studies in the synthesis of a monoterpenoid alkaloid, chaksine. Diethyl methylmalonate was alkylated with 1,3-dibromo propane to give 2-(3-bromopropyl)-2-methylmalonate. Hydrolysis and decarboxylation of this product gave the mono acid which was then converted to the corresponding ethyl ester. Reduction with lithium borohydride yielded the primary alcohol to which a tetrahydropyran protective group was added. Alkylation with diethyl malonate followed by acylation with the mixed anhydride of isovaleric acid and carbobenzyloxyglycine gave diethyl (see document for formula).
dc.language.iso	en_US
dc.subject	Alkaloids Synthesis
dc.subject	Chaksine
dc.title	Synthetic studies on chaksine
dc.type	Thesis
etd.degree.name	Master of Science
etd.degree.level	Master
etd.degree.discipline	Chemistry
etd.degree.grantor	Lakehead University