Show simple item record

dc.contributor.advisorOrr, D.
dc.contributor.authorEvans, John Bruce
dc.date.accessioned2017-06-06T13:08:34Z
dc.date.available2017-06-06T13:08:34Z
dc.date.created1970
dc.date.issued1970
dc.identifier.urihttp://knowledgecommons.lakeheadu.ca/handle/2453/2203
dc.description.abstractThis thesis is concerned with the preliminary studies in the synthesis of a monoterpenoid alkaloid, chaksine. Diethyl methylmalonate was alkylated with 1,3-dibromo propane to give 2-(3-bromopropyl)-2-methylmalonate. Hydrolysis and decarboxylation of this product gave the mono acid which was then converted to the corresponding ethyl ester. Reduction with lithium borohydride yielded the primary alcohol to which a tetrahydropyran protective group was added. Alkylation with diethyl malonate followed by acylation with the mixed anhydride of isovaleric acid and carbobenzyloxyglycine gave diethyl (see document for formula).
dc.language.isoen_US
dc.subjectAlkaloids Synthesis
dc.subjectChaksine
dc.titleSynthetic studies on chaksine / by John Bruce Evans
etd.degree.nameM.Sc.
etd.degree.levelMaster
etd.degree.disciplineChemistry
etd.degree.grantorLakehead University


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record