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In vitro detection of apoptosis using superparamagnetic iron oxide nanoparticles and molecular magnetic resonance imaging

dc.contributor.advisorRapley, Patrick
dc.contributor.authorRich, Katy
dc.date.accessioned2012-11-11T02:34:16Z
dc.date.available2012-11-11T02:34:16Z
dc.date.created2010-01
dc.date.issued2010
dc.identifier.urihttp://knowledgecommons.lakeheadu.ca/handle/2453/252
dc.description.abstractSuperparamagnetic iron oxide (SPIO) nanoparticles have the potential to greatly expand current anatomical imaging techniques, specifically MRI. SPIO nanoparticles targeted to phosphatidylserine (PS) have the potential to detect cell death in vitro . In this investigation, a method for detecting apoptosis was developed using annexin V for targeting SPIO nanoparticles to PS thus enabling us to detect different levels of cell death using a clinical MRI. The results demonstrated that the presence of MACS MicroBeads (annexin V-SPIO) leads to an increase in image contrast in the regions of large numbers of apoptotic cells ... Results show poor agreement with theoretical predictions but still offer potential improvement over previous efforts using SPECT imaging. The work presented here has implications for future studies of cancer treatment response and may one day help detect and quantify the levels of apoptosis in order to modify treatment according to specific patient needs.en_US
dc.language.isoen_USen_US
dc.subjectApoptosisen_US
dc.subjectMagnetic resonance imagingen_US
dc.titleIn vitro detection of apoptosis using superparamagnetic iron oxide nanoparticles and molecular magnetic resonance imagingen_US
dc.typeThesisen_US
etd.degree.nameMaster of Science
etd.degree.levelMasteren_US
etd.degree.disciplinePhysicsen_US
etd.degree.grantorLakehead Universityen_US
dc.contributor.committeememberLinhananta, Apichart
dc.contributor.committeememberSears, William


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