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    Variability of ionic magnesium

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    JohnsonK2001m-1b.pdf (1.673Mb)

    Date

    2001

    Author

    Johnson, Kristien Paul

    Degree

    Master of Science

    Discipline

    Kinesiology

    Subject

    Electrodes, Ion selective
    Magnesium ions
    Magnesium in the body

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    Abstract

    With the invention o f the ion-selective electrode, ionic magnesium (iMg), the biologically active form of Mg, is a common blood assay. There is some evidence that iMg has considerable within subject variability. To further assess this, blood samples were collected from 13 healthy volunteers 6X/day (7:00 - 22:00, every 3 hours) for 3 consecutive days and analysed for iMg (NOVA Stat 8 Analyser). Individual ranges averaged .08 mmol/L (range .05 to .14). Coefficients of variation (CV) ranged from 3% to 7% (mean 4%) while analytical variation was determined to be 2.3%. Biological variability thus accounts for almost half of the variability which is clinically significant as 9 of the 13 subjects recorded at least one value below a reference range of .46 - .60 mmol/L. A significant within day variation (p<.001) was noted, with differences between 7:00 and 10:00 as well as 10:00 and 22:00. Between day variations were not significant (p=.56). A plausible explanation of this data is that iMg has a circadian rhythm, but a sinusoidal curve of best fit computed for each subject did not correlate highly to iMg (r=.20). Thus, cautious interpretation of iMg values is warranted until future research determines the nature of iMg variability.

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    http://knowledgecommons.lakeheadu.ca/handle/2453/3167

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