| dc.description.abstract | Measurement of hemodialysis treatment adequacy is essential to monitor quality
assurance for today’s growing dialysis population. The universally accepted measure of
hemodialysis dose is Kt/V. Kt/V above 1.2 has been shown to reduce patient morbidity and
mortality. Currently, Kt/V is calculated from urea kinetic modelling using predialysis and
postdialysis blood samples. This blood-based approach, as well as being costly and invasive, is
typically performed once a month providing only periodic snapshots of dialysis adequacy.
Methods to provide more frequent feedback to attending doctors have been developed based on
urea concentration sensors in the spent dialysate stream. More recently, monitoring of dialysate
conductivity in the spent dialysate stream has been proposed as an alternative to urea monitoring
— ionic dialysance has been found to be highly correlated to urea clearance. The subject of this
thesis is the kinetic modelling o f spent dialysate conductivity.
The following single pool equation was developed to describe the kinetics of the spent
dialysate conductivity during periods of constant inlet dialysate conductivity: (see document) | |
