Browsing by Committee Member
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Coordination chemistry of bithiazole ligands: a comparative study of the 2,2’ and 4,4’ isomers
(2019)The bithiazole ring system consists of two thiazole (C3NS) aromatic rings. There are many regioisomers but two of potential interest for coordination chemistry are the 2,2’-bis(1,3-thiazole) and the 4,4’-bis(1,3-thiazole), ... -
Design and synthesis of small molecule ligands targeting protease-activated receptor 2 as potential diagnostic and therapeutic agents
(2021)Positron emission tomography (PET) imaging requires radionuclides (positron-emitters) labeled molecules (tracers) to image biochemical and physiological processes in vivo and helps diagnose diseases noninvasively. The ... -
The design of Zr metal-organic frameworks in the detection and neutralization of organophosphorus based nerve agents and pesticides
(2022)Organophosphates are ubiquitous in uses ranging from chemical warfare agents (CWA’s) to detergents. In between these two extreme uses lie organophosphorus-based agrichemicals, primarily pesticides, which are applied in ... -
The development of molecular probes for the in vitro and in vivo study of glucocerebrosidase
(2017)Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases in the world. Despite its prevalence, the disease is difficult to diagnose early with the vast majority of individuals already having significant ... -
Development of multi-probe fluorescence-based assay for boNTA detection
(2015-08-05)Botulinum neurotoxins (BoNTs) cause the lethal disease botulism through the inhibition of acetyl choline secretion by the cleavage of crucial SNARE proteins. Determination of critical residues in the protein sequence of ... -
Efficacy of a multimolecular extraction from formalin-fixed paraffin-embedded tissue
(2021)As the genetic basis and gene expression components are being discovered for an increasing number of diseases and disorders there is a rising interest in using multiomic approaches to better understand these conditions. ...
