Now showing items 1-7 of 7
The stereochemical impact of chiral ionic liquids on [2+2] photochemical cycloadditions and aldol reactions
Eight chiral ionic liquids have been prepared for use as solvents to test whether they can induce enantioselectivity in both photochemical [2+2] cycloadditions and aldol reactions using a variety of starting materials. ...
Sulfo-functionalization of lignin and its impact on the stabilization of colloidal systems
Lignin macromolecules, derived from renewable biomass resources, have gained extensive interest during the past decade as a sustainable substitute for synthetic oil-based materials. The main goal of this dissertation was ...
Expansion of the applicability of the Truce-Smiles rearrangement
The Truce-Smiles rearrangement is a synthetically useful and easily performed reaction which can be used to condense multiple steps of a synthesis. The nucleophilic aromatic substitution in this reaction produces a chiral ...
Design and synthesis of small molecule ligands targeting protease-activated receptor 2 as potential diagnostic and therapeutic agents
Positron emission tomography (PET) imaging requires radionuclides (positron-emitters) labeled molecules (tracers) to image biochemical and physiological processes in vivo and helps diagnose diseases noninvasively. The ...
The design of Zr metal-organic frameworks in the detection and neutralization of organophosphorus based nerve agents and pesticides
Organophosphates are ubiquitous in uses ranging from chemical warfare agents (CWA’s) to detergents. In between these two extreme uses lie organophosphorus-based agrichemicals, primarily pesticides, which are applied in ...
18F Radiolabeling of epidermal growth factor receptor-tyrosine kinase inhibitor anti-cancer drugs for therapeutic outcome studies
Epidermal growth factor receptor is a transmembrane protein with tyrosine kinase activity that plays a vital role in the proliferation, differentiation, and survival of normal cells. When mutations in this protein occur, ...