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The stereochemical impact of chiral ionic liquids on [2+2] photochemical cycloadditions and aldol reactions
(2020)
Eight chiral ionic liquids have been prepared for use as solvents to test whether they can
induce enantioselectivity in both photochemical [2+2] cycloadditions and aldol reactions using a
variety of starting materials. ...
Sulfo-functionalization of lignin and its impact on the stabilization of colloidal systems
(2021)
Lignin macromolecules, derived from renewable biomass resources, have gained extensive interest
during the past decade as a sustainable substitute for synthetic oil-based materials. The main goal
of this dissertation was ...
Expansion of the applicability of the Truce-Smiles rearrangement
(2022)
The Truce-Smiles rearrangement is a synthetically useful and easily performed reaction
which can be used to condense multiple steps of a synthesis. The nucleophilic aromatic
substitution in this reaction produces a chiral ...
Design and synthesis of small molecule ligands targeting protease-activated receptor 2 as potential diagnostic and therapeutic agents
(2021)
Positron emission tomography (PET) imaging requires radionuclides (positron-emitters) labeled
molecules (tracers) to image biochemical and physiological processes in vivo and helps diagnose
diseases noninvasively. The ...
The design of Zr metal-organic frameworks in the detection and neutralization of organophosphorus based nerve agents and pesticides
(2022)
Organophosphates are ubiquitous in uses ranging from chemical warfare agents
(CWA’s) to detergents. In between these two extreme uses lie organophosphorus-based
agrichemicals, primarily pesticides, which are applied in ...
18F Radiolabeling of epidermal growth factor receptor-tyrosine kinase inhibitor anti-cancer drugs for therapeutic outcome studies
(2023)
Epidermal growth factor receptor is a transmembrane protein with tyrosine kinase activity that plays a vital role in the proliferation, differentiation, and survival of normal cells. When mutations in this protein occur, ...
Biological studies of muramyl dipeptide analogues as potential ligands for NOD2 receptor
(2023)
The human body’s survival against various foreign disease-causing organisms solely depends on
the protection provided by our body's immune system. Our body's complex yet effective
immune system comprises cells, molecules ...
Development of an 18F radiolabeling method using solid phase chemistry
(2023)
New radiotracers are constantly being developed to expand the clinical applications of
positron emission tomography (PET). One of the challenges in the development of PET tracers
is the incorporation of a positron emitting ...
Design, synthesis, and evaluation of novel lysophosphatidic acid receptor-targeting small molecules as therapeutic and diagnostic agents
(2023)
Breast cancer has the highest incidence rate of all cancers among Canadian women and
accounts for nearly 14% of all cancer-related deaths in Canada. This type of cancer is often
detected using medical imaging modalities ...