Browsing by Discipline
Now showing items 21-40 of 138
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The carcinogenic properties of naturally occurring human papillomavirus 16 E6 oncogene variants
(2013-02-03)Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical cancer, which is the result of expression of the E6 and E7 oncogenes. Here we challenged the dogma that the oncogenic protein ... -
Causes and consequences of population changes in Black Bay Steelhead, Lake Superior
(2019)Understanding species interactions is an important component of fisheries resource management. Like the other Great Lakes, Lake Superior’s fish species composition (and therefore interactions among species) has been changing ... -
Characterization of an arsenite-oxidizing caballeronia sp. soil bacterium and its mutualistic relationship with trifolium pratense for arsenic remediation
(2021)The proposed application of the mutualistic interaction between a native arsenicoxidizing soil bacteria and Trifolium pratense in Northwestern Ontario mine sites is a novel approach to remediation. This thesis studies the ... -
Characterization of rainbow trout (Oncorhynchus mykiss) and fathead minnow (Pimephales promelas) cell lines as models to study pulp and paper effluent effects in fish
(2012-11-10)The effects of aquatic toxicants on fish growth and development have been well-documented, in contrast to the changes in gene expression that necessarily precede them. Many of these toxicants are exogenous compounds that ... -
Characterization of sediment, sewage and 0157 E. coli: a comparison of their virulence genes, biofilm forming capacities, antibiotic resistance and level of reactive oxygen species (ROS)
(2018)Even though sediment Escherichia coli is a common source of contamination in freshwater environments, their virulence and physiological characteristics are not well studied. The goal of this study was to compare the virulence ... -
Chemoreception in invasive rusty crayfish (Orconectes rusticus): learning and adaptation in aquatic ecosystems of Northwestern Ontario
(2012-11-10)Crayfish utilize chemosensory cues, in addition to other sensory inputs, to mediate a variety of fundamental life processes. Exotic species, like the rusty crayfish (Orconectes rusticus), are known to employ a broader ... -
A combined method for establishing keratinocyte cultures from cervical biopsy specimens and creating patent-derived 3-dimensional organotypic raft cultures
(2018)High-risk types of human papillomavirus (HPV) are responsible for nearly all instances of cervical cancer, and a significant proportion of head and neck cancers. Studying HPV in the laboratory requires the cultivation of ... -
Comparing Canonical and Dicer Substrate Small Interfering RNA and Their Effects on the Silencing of Two Common Human Papillomavirus 16 E6 Variants
(2015)High-risk human papillomaviruses (HPVs), such as HPV16, cause nearly all cases of cervical cancer as well as a number of head and neck cancers. Over expression of the E6 oncoprotein helps drive the malignant phenotype, ... -
Critical decisions: risk allocation in a model arthropod (Folsomia candida)
(2015-06-15)Risk allocation theory predicts that foraging animals moderate predation risk by allocating their foraging effort and space use according to their energetic demands. Undernourished animals have a greater need for energy ... -
The cumulative effects of hypoxia and hyperglycemia on cardiac oxidative stress
(2014-01-22)Hyperglycaemia-induced oxidative stress plays an important role in cardiomyocyte cell death leading to cardiac dysfunction. Autophagy is an intracellular bulk degradation process and can be induced by stressors such as ... -
Cystathionine γ-lyase and hypoxia : implicating hydrogen sulfide in the hypoxic stress response
(2012-11-10)Hydrogen sulfide (H2 S) has emerged as a novel and important gasotransmitter for the cardiovascular system, where it is generated mainly by cystathionine γ-lyase (CSE). Abnormal metabolism and functions of the H2 S/CSE ... -
The Decline of a Northern Lake Superior marsh : a study of the cause and effect
(2009)This study quantified the loss of vegetation in Mission Marsh located within the city limits of Thunder Bay on the northern shore of Lake Superior, suggested the most likely cause of this vegetation loss, and examined in ... -
Density-dependent habitat selection alters fitness in a clonal hexapod
(2019)Density-dependent habitat selection shapes the distribution and abundance of organisms and thus informs our understanding of the eco-evolutionary process. When habitat choice is contingent on an individual’s expectation ... -
Detection and characterization of DNA damage
(2009)The DNA molecule is constantly subjected to endogenous and exogenous sources of damage which if left unrepaired can lead to genotoxic and cytotoxic outcomes. These lesions have been implicated in the development of numerous ... -
Detection of Deoxyribonucleic Acid Damage Induced by Metal Ion Interactions and Repair of Metal Ion Deoxyribonucleic Acid Cross-links
(2010-08-17)There are many forms of DNA damage. One of these, DNA-metal cross-links are particularly problematic as they not only affect the tautomeric structure of DNA, but can also inhibit enzymatic activity and block amplification ... -
Developing a Multiplex PCR Platform to Determine the Virulence Genes of Escherichia Coli in Boulevard Lake, Thunder Bay, Ontario
Given the evidence that E. coli can establish in the periphytic community and be released back into the water column, it is important to understand the pathogenicity of this group of E. coli by examining the virulence genes ... -
Diagnostic and treatment approaches to fibromyalgia management: quantification of peripheral blood mononuclear cell function and evaluation of radial shockwave therapy
(2019)Fibromyalgia (FM) is a chronic pain disorder that affects many individuals worldwide. The lack of a definitive diagnostic method and highly successful treatment approaches make it an interesting area of research. In the ... -
Diatoms as an indicator of pharmaceutical contamination in a freshwater system
(2018)Historically, microalgae have been used as bio-indicators of aquatic health and this can be seen in several studies across the world. Often at the bottom of the food chain, microalgae constitute the primary producer of ... -
Differential response of two common human papillomavirus 16 E6 variants to small interfering RNA
(2014-01-22)High-risk human papillomaviruses (HPVs), such as HPV16, are implicated in causing virtually all cases of cervical cancer. Molecular therapies capable of targeting HPV16 E6 oncoprotein expression can selectively eliminate ... -
Does fire severity difference create divergent plant communities in black spruce-Kalmia forests of eastern Canada?
(2009-06-25)After fire, some conifer-ericaceous plant communities in Western Europe and eastern North America have demonstrated divergent succession from traditional conifer stand replacement to Ericaceae-dominated community states. ...