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The Role of free- and liposomal-N-acetycysteine in paraquat-induced cytotoxicity

dc.contributor.advisorSuntres, Zacharias
dc.contributor.authorMitsopoulos, Panagiotis
dc.date.accessioned2012-11-11T02:49:54Z
dc.date.available2012-11-11T02:49:54Z
dc.date.created2009-09
dc.date.issued2012-11-10
dc.identifier.urihttp://knowledgecommons.lakeheadu.ca/handle/2453/265
dc.description.abstractParaquat (PQ), one of the most commonly used herbicides worldwide, is hightly toxic to humans and exposure can result in severe clinical situations with no effective treatments available. The toxicity of PQ has been attributed to its ability to continuously produce reactive oxygen species (ROS) via redox cycling. Oxidants have been shown to induce the expression of several early response genes and to activate transcription factors, which may contribute to the inflammatory response associated with PQ injury.en_US
dc.language.isoen_USen_US
dc.subjectParaquaten_US
dc.subjectToxicologyen_US
dc.subjectHerbicidesen_US
dc.subjectN-acetycysteineen_US
dc.subjectCell-mediated cytotoxicityen_US
dc.subjectLiposomesen_US
dc.subjectOxidation-reduction reactionen_US
dc.subjectAntioxidantsen_US
dc.titleThe Role of free- and liposomal-N-acetycysteine in paraquat-induced cytotoxicityen_US
dc.typeThesisen_US
etd.degree.nameM.Sc.
etd.degree.levelMasteren_US
etd.degree.disciplineBiologyen_US
etd.degree.grantorLakehead Universityen_US
dc.contributor.committeememberKhaper, Neelam
dc.contributor.committeememberLaw, David
dc.contributor.committeememberMalek, Ladislav


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