Browsing by Committee Member
Now showing items 1-20 of 25
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The antioxidant resveratrol down-regulates inflammation in an in vitro model of Pseudomonas aeruginosa infection of lung epithelial cells
(2014-01-22)Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen capable of infecting the lungs and causing severe pulmonary disease in immunocompromised individuals. During the infectious process, P. aeruginosa provokes ... -
Aspects of infectious agents and cancer : effects of human Papillomavirus 16 and Escherichia coli on the innate immune defense of human keratinocytes
(2012-11-10)Persistent human papillomavirus (HPV) is the causative agent of cervical cancer and bacterial vaginosis (BV) caused by Escherichia coli (E. coli ) has been implicated as a contributing factor. The innate immune system is ... -
The carcinogenic properties of naturally occurring human papillomavirus 16 E6 oncogene variants
(2013-02-03)Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical cancer, which is the result of expression of the E6 and E7 oncogenes. Here we challenged the dogma that the oncogenic protein ... -
Characterization of an arsenite-oxidizing caballeronia sp. soil bacterium and its mutualistic relationship with trifolium pratense for arsenic remediation
(2021)The proposed application of the mutualistic interaction between a native arsenicoxidizing soil bacteria and Trifolium pratense in Northwestern Ontario mine sites is a novel approach to remediation. This thesis studies the ... -
Cystathionine gamma-lyase/hydrogen sulfide system and glucose homeostasis
(2013-02-12)Research in the last twenty years has transformed the role of hydrogen sulfide (H2S) being perceived from a toxic gas to a gaso-transmitter with diverse physiological and pathological significance. Cystathionine gamma-lyase ... -
Detection and characterization of DNA damage
(2009)The DNA molecule is constantly subjected to endogenous and exogenous sources of damage which if left unrepaired can lead to genotoxic and cytotoxic outcomes. These lesions have been implicated in the development of numerous ... -
Developing a Multiplex PCR Platform to Determine the Virulence Genes of Escherichia Coli in Boulevard Lake, Thunder Bay, Ontario
Given the evidence that E. coli can establish in the periphytic community and be released back into the water column, it is important to understand the pathogenicity of this group of E. coli by examining the virulence genes ... -
Diagnostic and treatment approaches to fibromyalgia management: quantification of peripheral blood mononuclear cell function and evaluation of radial shockwave therapy
(2019)Fibromyalgia (FM) is a chronic pain disorder that affects many individuals worldwide. The lack of a definitive diagnostic method and highly successful treatment approaches make it an interesting area of research. In the ... -
Differential response of two common human papillomavirus 16 E6 variants to small interfering RNA
(2014-01-22)High-risk human papillomaviruses (HPVs), such as HPV16, are implicated in causing virtually all cases of cervical cancer. Molecular therapies capable of targeting HPV16 E6 oncoprotein expression can selectively eliminate ... -
Effect of biofilm and the role of rpoS on the survival of a p-Nitrophenol-degrading Pseudomonas putida / by Miranda Maki.
(2008)Pseudomonas putida is a Gram negative bacterium that can be found naturally in the environment as planktonic free-living cells, or in concert with other bacterial species in biofilms. In this study, the P. putida strain ... -
Effect of periphytic Escherichia coli and lake water bacterial population on the biofilm establishment of a Shiga toxin producing Escherichia coli O157:H7 strain
(2015)Biofilm studies Escherichia coli (E. coli) have typically focused on 0157:H7 in defined, laboratory medium. While there is value in such studies, they offer little in the way of explaining the behaviour and interactions ... -
The effect of polyphenols on the angiotensin II receptor type 1 activation
(2017)Hypertension, an increase in blood pressure, can lead to many serious complications, one of which is heart failure. Angiotensin (Ang) II is associated with hypertension; specifically, the Ang II receptor type 1 (AGTR1) is ... -
The effect of secoisolariciresinol diglucoside on oxidative stress and inflammation in cardiac iron overload
(2013-02-01)Chronic cardiac iron overload directly correlates with cardiac dysfunction and may ultimately cause heart failure. Although recent studies have suggested that altered calcium homeostasis and increased reactive oxygen ... -
Engineering fungi for boosting cellulase production and its potential industrial application
(2013-02-03)Bioconversion of lignocellulosic residues is initiated primarily by microorganisms such as fungi and bacteria which are capable of degrading lignocellulolytic materials. Fungi produce large amounts of extracellular ... -
Freeze-thaw effect on selected fecal indicator bacteria : Escherichia coli and Enterococcus faecalis / by Nicole A. Hawdon.
(2008)The survival of two selected fecal indicator organisms, two strains of Escherichia coli, a Gram-negative bacterium, and two strains of Enterococcus faecalis, a Gram-positive bacterium, after freezing and thawing successively ... -
Humoral immunity in patients with chronic kidney disease and their response to pneumococcal immunization
(2020)In northwestern Ontario the Indigenous First Nations (FN) population have an increased prevalence of chronic kidney disease (CKD). There is an increased rate of infectious disease caused by Streptococcus pneumoniae ... -
Lignin Degradation by some wood-rot fungi with emphasis on cylindrocladium camelliae
(2012-11-10)Thirty wood-rot fungi were screened for their ability to grow on media containing Kraft lignin with a limited amount of glucose. Of these fungi, twenty-three were tested for ligninolytic activity judged by decolorization ... -
Lowbush blueberries in Northwestern Ontario as a commercial crop option in post-harvest peatlands
(2009-10-15)Wild blueberries (Vaccinium angustifolium Ait.) were investigated as a possible reclamation tool for post harvest peatlands in Northwestern Ontario, by genetic fingerprinting using microsatellite markers, an examination ... -
Neutrophils in the interface between innate and adaptive immunity in response to Haemophilus influenzae type a
(2022)Haemophilus influenzae type a (Hia) is a bacterial human pathogen that has emerged as a significant cause of invasive disease in Canadian Indigenous populations. Protection against encapsulated bacteria such as Hia is ... -
One-step inactivation of rpoS to investigate its role on Escherichia coli O157:H7 biofilm formation and survival
(2009)Homologous linear recombination using the recombinogenic capabilites of phage red genes exo, bet and gam, has been used increasingly to generate targeted gene replacements in Gram-negative bacteria.
