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Assessing in vitro DNA repair methods / by Ryan Lehto.
(2010)The DNA molecule is constantly under attack from endogenous and exogenous sources leading to degradation by a variety of forms of damage. In this study current methods of in vitro DNA repair methods were evaluated for ... -
The carcinogenic properties of naturally occurring human papillomavirus 16 E6 oncogene variants
(2013-02-03)Human papillomavirus is the causative agent of the 2nd highest occurring cancer in women, cervical cancer, which is the result of expression of the E6 and E7 oncogenes. Here we challenged the dogma that the oncogenic protein ... -
Comparing Canonical and Dicer Substrate Small Interfering RNA and Their Effects on the Silencing of Two Common Human Papillomavirus 16 E6 Variants
(2015)High-risk human papillomaviruses (HPVs), such as HPV16, cause nearly all cases of cervical cancer as well as a number of head and neck cancers. Over expression of the E6 oncoprotein helps drive the malignant phenotype, ... -
Cystathionine γ-lyase and hypoxia : implicating hydrogen sulfide in the hypoxic stress response
(2012-11-10)Hydrogen sulfide (H2 S) has emerged as a novel and important gasotransmitter for the cardiovascular system, where it is generated mainly by cystathionine γ-lyase (CSE). Abnormal metabolism and functions of the H2 S/CSE ... -
Development of bacterial systems for the production of cellulase and bioethanol
(2013-02-01)The wide varieties of extant bacterial species are often resistant to various environmental stresses. This demonstrates their frequent ability to adapt to and thrive in challenging environments. One such adaptation in ... -
The effects of copper, calcium, and nickel on the olfactory response of fathead minnows: from neurophysiology to behaviour
(2014-01-22)The olfactory system is essential for a fish to be successful in an ecological context, and has been demonstrated to be sensitive to a variety of toxicants. The current biotic ligand model (BLM) for copper is an acute-toxicity ... -
Effects of water availability, longer photoperiod, and elevated [CO2] on the potential of the northward migration in trembling aspen (populus tremuloides michx.)
(2019)Based on climate envelope models, boreal tree species may migrate to higher latitudes (approximately 10˚N toward the north) in response to rapid climate changes by the end of this century. Multiple factors will likely ... -
Engineering fungi for boosting cellulase production and its potential industrial application
(2013-02-03)Bioconversion of lignocellulosic residues is initiated primarily by microorganisms such as fungi and bacteria which are capable of degrading lignocellulolytic materials. Fungi produce large amounts of extracellular ... -
Fetal programming from sub-lethal radiation: glucose metabolism in the liver and brown adipose tissue
(2018)Exposure to ionizing radiation contributing to negative health outcomes is a widespread concern among the public, scientific community, and workers in the nuclear energy industry and diagnostic imaging field. However, ... -
Increased production of sugar streams from lignocellulosic materials through enzyme recycling
(2019)The Canadian pulp and paper mills generate over 1 million tons of primary sludge per year. This sludge mainly contains small cellulosic fibers and contaminants from pulp and paper manufacture and is usually disposed of by ... -
Lowbush blueberries in Northwestern Ontario as a commercial crop option in post-harvest peatlands
(2009-10-15)Wild blueberries (Vaccinium angustifolium Ait.) were investigated as a possible reclamation tool for post harvest peatlands in Northwestern Ontario, by genetic fingerprinting using microsatellite markers, an examination ... -
A multiomic approach to paleogenetic investigation of ancient North American bison
(2018)Twelve ancient bison bone samples from north-central North America were examined using genetic and proteomic sequencing to determine relationships to other bison populations. Mitochondrial DNA sequences suggest a genetic ... -
One-step inactivation of rpoS to investigate its role on Escherichia coli O157:H7 biofilm formation and survival
(2009)Homologous linear recombination using the recombinogenic capabilites of phage red genes exo, bet and gam, has been used increasingly to generate targeted gene replacements in Gram-negative bacteria. -
Physiological and morphological responses of mountain maple (acer spicatum l.) seedlings to light under different carbon dioxide concentrations, soil temperature and soil moisture regimes
(2013-02-01)Determining the response of mountain maple (Acer spicatum L.) to increases in light is confounded by interaction with other environmental factors. Rising atmospheric carbon dioxide concentrations ([CO2]) and the accompanying ... -
The Role of free- and liposomal-N-acetycysteine in paraquat-induced cytotoxicity
(2012-11-10)Paraquat (PQ), one of the most commonly used herbicides worldwide, is hightly toxic to humans and exposure can result in severe clinical situations with no effective treatments available. The toxicity of PQ has been ... -
Utilization of alternative testing methods in the evaluation of pulp and paper mill effluent toxicity
(2020)Pulp mills are required to perform routine regulatory testing to ensure the effluent they release from their water treatment plants is not harmful to humans and the environment. The key components within the effluent ...