Browsing by Committee Member
Now showing items 1-17 of 17
-
The antioxidant resveratrol down-regulates inflammation in an in vitro model of Pseudomonas aeruginosa infection of lung epithelial cells
(2014-01-22)Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen capable of infecting the lungs and causing severe pulmonary disease in immunocompromised individuals. During the infectious process, P. aeruginosa provokes ... -
Aspects of infectious agents and cancer : effects of human Papillomavirus 16 and Escherichia coli on the innate immune defense of human keratinocytes
(2012-11-10)Persistent human papillomavirus (HPV) is the causative agent of cervical cancer and bacterial vaginosis (BV) caused by Escherichia coli (E. coli ) has been implicated as a contributing factor. The innate immune system is ... -
Campylobacter jejuni : biofilm formation and oxidative stress
(2009)Campylobacter jejuni (C. jejuni) is a zoonotic pathogen most often associated with poultry and the leading cause of bacterial gastroenteritis in the developed world. It is an obligate microaerobe, requiring low levels of ... -
Characterization of sediment, sewage and 0157 E. coli: a comparison of their virulence genes, biofilm forming capacities, antibiotic resistance and level of reactive oxygen species (ROS)
(2018)Even though sediment Escherichia coli is a common source of contamination in freshwater environments, their virulence and physiological characteristics are not well studied. The goal of this study was to compare the virulence ... -
A combined method for establishing keratinocyte cultures from cervical biopsy specimens and creating patent-derived 3-dimensional organotypic raft cultures
(2018)High-risk types of human papillomavirus (HPV) are responsible for nearly all instances of cervical cancer, and a significant proportion of head and neck cancers. Studying HPV in the laboratory requires the cultivation of ... -
Exploration of inflammasomes as targets for therapy of Pseudomonas aeruginosa infection
(2018)Pseudomonas aeruginosa is a common Gram-negative opportunistic bacterial pathogen capable of infecting humans with compromised natural defenses and causing severe pulmonary disease. It is the major cause of severe chronic ... -
H2S as a novel biomarker and therapeutic target for asthma
(2015)Asthma is a chronic inflammatory disease with hyper-responsive bronchoconstriction and airway remodeling, leading to extensive airway narrowing. The pathophysiology of asthma remains unclear. The literature shows that the ... -
H2S S-sulfhydration of pyruvate carboxylase in gluconeogenesis and its regulation by Trx1
(2015)Hydrogen sulfide (H2S), regarded as the third gasotransmitter, plays diverse physiological and pathological roles in the body along with another two gasotransmitters, including nitric oxide (NO) and carbon monoxide (CO). ... -
Hydrogen sulfide modulates gluconeogenesis and mitochondrial biogenesis in mouse primary hepatocytes
(2016)Among many endogenous substances that regulate hepatic energy production is the gasotransmitter hydrogen sulfide (H2S). In the liver, H2S production is largely catalyzed by cystathionine γ-lyase (CSE) and, to a lesser ... -
Lipoic acid and its potential role in the treatment of oxidative-induced injury of A549 lung epithelial cells
(2013-02-01)Oxidative stress is the imbalance between prooxidants and antioxidants within a cell that can cause and/or contribute to the progression of many pathological conditions. Reactive oxygen species (ROS) formed from the ... -
Measuring S100B in concussed athletes following a maximal aerobic fitness test
(2009)An objective biological test to measure concussion may provide further insight into a player's decision to return-to-play. Protein S100B is a calcium-binding protein that has been studied as a sensitive biomarker of central ... -
Nanomaterials based electrochemical approaches for biosensing and bacterial disinfection
(2017)Electrochemical approaches to myriad medical and environmental challenges are highly attractive due to their strong potential for extensive and green applications. Point of care diagnostics through the electrochemical ... -
Neutrophils in the interface between innate and adaptive immunity in response to Haemophilus influenzae type a
(2022)Haemophilus influenzae type a (Hia) is a bacterial human pathogen that has emerged as a significant cause of invasive disease in Canadian Indigenous populations. Protection against encapsulated bacteria such as Hia is ... -
Physiological adaptations contributing to stress survival in the foodborne pathogen Campylobacter jejuni
(2015-06-15)n spite of being considered fragile and fastidious, the zoonotic pathogen Campylobacter jejuni remains the leading cause of foodborne bacterial gastroenteritis in the developed world. Lacking many of the stress responses ... -
The Role of free- and liposomal-N-acetycysteine in paraquat-induced cytotoxicity
(2012-11-10)Paraquat (PQ), one of the most commonly used herbicides worldwide, is hightly toxic to humans and exposure can result in severe clinical situations with no effective treatments available. The toxicity of PQ has been ... -
Skeletal muscle adaptation in response to chronic oral corticosterone treatment in C57BL/6N mice
(2023)Chronic exposure to elevated glucocorticoid levels represents a significant concern for researchers, healthcare professionals, and the general public. In various disorders and diseases (such as Cushing Syndrome and major ... -
Study of the activation of the inflammasome protein complex by Haemophilus influenzae Type a
(2021)Haemophilus influenzae (Hi) is a gram-negative bacterium capable of causing severe invasive infection such as meningitis and is classified by the presence or absence of polysaccharide capsule. The polysaccharide capsule ...
