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Assessing and characterizing the inductive effect through silicon containing backbones and on silicon reactivity
This thesis describes a study of the inductive effect in derivatives of bicyclo[1.1.1.]pentane; chosen because it eliminates any possibility of conjugation between the substituent and probe, and keeps the steric effect ...
An investigation of saccharide complexation by aqueous oxoacids. Can oxoacids mediate A1-2 quorum sensing in bacteria?
The goal of this investigation was to determine whether it is plausible for bacterial AI-2 quorum sensing to be selectively regulated by environmentally available oxoacids. In particular, we investigated the ability of ...
Gallium nitride, indium nitride, and heterostructure development using the MEAglow growth system
This thesis presents an in depth study of semiconductor development using a new process termed Migration Enhanced Afterglow (MEAglow). The MEAglow growth reactor is housed in the Lakehead University Semiconductor Research ...
Ruthenium piano stool complexes incorporating novel bis(pyrrolidinyl)alkylphosphines
Conventional phosphine ligands (i.e., those typically bearing alkyl and/or aryl substituents) have played a crucial role in the development of transition metal coordination chemistry. Many structural and electronic variants ...
Computational tools for the high-throughput identification of protein-targeted drugs and probes
This thesis is comprised of three projects that are driven by a common theme, which is the use of computational tools in aiding molecular probe and drug design. In the first project, the feasibility of using molecular ...
Potential dual purpose molecular probe for HPV16 E6: a computational and experimental approach
The goal of this project is to find a molecular probe for HPV variant 16 protein E6. This
goal is accomplished using a combination of Virtual Ligand Screening (VLS) and experimental
ligand binding assays.
Protein E6 is ...
Development of multi-probe fluorescence-based assay for boNTA detection
Botulinum neurotoxins (BoNTs) cause the lethal disease botulism through the inhibition of acetyl choline secretion by the cleavage of crucial SNARE proteins. Determination of critical residues in the protein sequence of ...
The design, synthesis and enzymatic evaluation of aminocyclitol inhibitors of glucocerebrosidase
Gaucher disease, the most common lysosomal storage disorder, is caused by mutations in the GBA gene which codes for the enzyme glucocerebrosidase (GCase) resulting in its deficiency. GCase deficiency results in the ...
Synthesis and electrochemical study of palladium-based nanomaterials for green energy applications
Rising global energy consumption leads to increased environmental impacts. The continued use of current energy resources, e.g. fossil fuels, will exaggerate the cumulative nature of CO2 byproduct emissions in the atmosphere. ...