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Physiological adaptations contributing to stress survival in the foodborne pathogen Campylobacter jejuni
(2015-06-15)
n spite of being considered fragile and fastidious, the zoonotic pathogen Campylobacter jejuni remains the leading cause of foodborne bacterial gastroenteritis in the developed world. Lacking many of the stress responses ...
Functional Imaging of the Lungs using Magnetic Resonance Imaging of Inert Fluorinated Gases
(2016)
Fluorine-19 (19F) magnetic resonance imaging (MRI) of the lungs using inhaled inert fluorinated gases can potentially provide high quality anatomical and functional images of the lungs. This technique is able to visualize ...
Improving Novel Gene Discovery in High-Throughput Gene Expression Datasets
(2012-11-10)
High-throughput gene expression datasets (including RNA-seq and microarray datasets) can quantify the expression level of tens of thousands of genes in an organism, which allows for the identification of putative functions ...
Submerged anaerobic membrane bioreactors for wastewater treatment and membrane fouling characterization and control
(2012-11-10)
This thesis focused on effects of transient conditions (pH shocks, temperature
variation and temperature shocks) on the performance and membrane fouling
characterization and control of submerged anaerobic membrane ...
Cystathionine gamma-lyase/hydrogen sulfide system and glucose homeostasis
(2013-02-12)
Research in the last twenty years has transformed the role of hydrogen sulfide (H2S) being perceived from a toxic gas to a gaso-transmitter with diverse physiological and pathological significance. Cystathionine gamma-lyase ...
Environmental Considerations for Wet Mining Peatlands in Northwestern Ontario
(2012-11-10)
Signi cant changes in water quality were detected using a Before-After-Control-Impact
(BACI) experimental design. Porewater showed increases in pH, alkalinity, conductivity
(including Ca, Mg, K, Na), some metals (Sr, Ba, ...
The effects of copper, calcium, and nickel on the olfactory response of fathead minnows: from neurophysiology to behaviour
(2014-01-22)
The olfactory system is essential for a fish to be successful in an ecological context, and has been demonstrated to be sensitive to a variety of toxicants. The current biotic ligand model (BLM) for copper is an acute-toxicity ...
Characterizing the microbial degradation of kraft lignin and lignin-derived compounds
(2014-12-12)
Analytical methods for characterizing the microbial degradation of Kraft lignin
and lignin-derived compounds were utilized with the goal of biologically generating
demethylated lignin for subsequent industrial applications. ...
Novel toll-like receptor 4 ligands: synthesis, biological studies and applications in molecular vaccines
(2015-06-15)
Lipid A, a unique disaccharide glycolipid, is the active principle of Gram-negative
bacterial lipopolysaccharide in activating the innate immune response via Toll-like
receptor 4 (TLR4). Given the important role that ...
Development of bacterial systems for the production of cellulase and bioethanol
(2013-02-01)
The wide varieties of extant bacterial species are often resistant to various environmental stresses. This demonstrates their frequent ability to adapt to and thrive in challenging environments. One such adaptation in ...